| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Drew Brees |
1. Drew Brees, QB | NO | L 41-36 at SEA | 39 | 60 | 404 | 2 | 0 | 1 | 0 | 95.4 |
| 2. Mike Vick, QB | PHI | L 21-16 vs. GB | 20 | 36 | 292 | 1 | 1 | 3 | 0 | 79.9 | |
| 3. Matt Hasselbeck, QB | SEA | W 41-36 vs. NO | 22 | 35 | 272 | 4 | 1 | 1 | 0 | 113.0 | |
| 4. Joe Flacco, QB | BAL | W 30-7 at KC | 25 | 34 | 265 | 2 | 0 | 4 | 1 | 115.4 | |
| 5. Peyton Manning, QB | IND | L 17-16 vs. NYJ | 18 | 26 | 225 | 1 | 0 | 1 | 0 | 108.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Marshawn Lynch |
1. Marshawn Lynch, RB | SEA | W 41-36 vs. NO | 19 | 131 | 6.9 | 1 | 67 | 0 | |
| 2. James Starks, RB | GB | W 21-16 at PHI | 23 | 123 | 5.3 | 0 | 27 | 0 | ||
| 3. Jamaal Charles, RB | KC | L 30-7 vs. BAL | 9 | 82 | 9.1 | 1 | 41 | 1 | ||
| 4. LaDainian Tomlinson, RB | NYJ | W 17-16 at IND | 16 | 82 | 5.1 | 2 | 23 | 0 | ||
| 5. Shonn Greene, RB | NYJ | W 17-16 at IND | 19 | 70 | 3.7 | 0 | 8 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Pierre Garcon |
1. Pierre Garcon, WR | IND | L 17-16 vs. NYJ | 5 | 112 | 22.4 | 1 | 57 | 0 | |
| 2. Todd Heap, TE | BAL | W 30-7 at KC | 10 | 108 | 10.8 | 0 | 21 | 0 | ||
| 3. Jason Avant, WR | PHI | L 21-16 vs. GB | 7 | 93 | 13.3 | 1 | 24 | 0 | ||
| 4. Devery Henderson, WR | NO | L 41-36 at SEA | 7 | 77 | 11.0 | 1 | 40 | 0 | ||
| 5. Brandon Stokley, WR | SEA | W 41-36 vs. NO | 4 | 73 | 18.3 | 1 | 45 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Glenn Dorsey |
1. Glenn Dorsey, DL | KC | L 30-7 vs. BAL | 8 | 3 | 11 | 0.0 | 0 | 0 | 0 |
| 2. Jovan Belcher, LB | KC | L 30-7 vs. BAL | 7 | 4 | 11 | 1.5 | 0 | 0 | 0 | |
| 3. Jamar Chaney, LB | PHI | L 21-16 vs. GB | 10 | 0 | 10 | 0.0 | 1 | 0 | 0 | |
| 4. Eric Berry, S | KC | L 30-7 vs. BAL | 9 | 1 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Eric Smith, S | NYJ | W 17-16 at IND | 7 | 3 | 10 | 0.0 | 0 | 0 | 0 | |