| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
C.J. Stroud |
1. C.J. Stroud, QB | HOU | W 32-12 vs. LAC | 22 | 33 | 282 | 1 | 1 | 3 | 0 | 90.7 |
| 2. Josh Allen, QB | BUF | W 31-7 vs. DEN | 20 | 26 | 272 | 2 | 0 | 2 | 0 | 135.4 | |
| 3. Russell Wilson, QB | PIT | L 28-14 at BAL | 20 | 29 | 270 | 2 | 0 | 4 | 0 | 121.3 | |
| 4. Jayden Daniels, QB | WSH | W 23-20 at TB | 24 | 35 | 268 | 2 | 0 | 1 | 0 | 110.2 | |
| 5. Sam Darnold, QB | MIN | L 27-9 at LAR | 25 | 40 | 245 | 1 | 1 | 9 | 1 | 77.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | BAL | W 28-14 vs. PIT | 26 | 186 | 7.2 | 2 | 44 | 0 | |
| 2. James Cook III, RB | BUF | W 31-7 vs. DEN | 23 | 120 | 5.2 | 1 | 19 | 0 | ||
| 3. Saquon Barkley, RB | PHI | W 22-10 vs. GB | 25 | 119 | 4.8 | 0 | 17 | 0 | ||
| 4. Joe Mixon, RB | HOU | W 32-12 vs. LAC | 25 | 106 | 4.2 | 1 | 17 | 1 | ||
| 5. Lamar Jackson, QB | BAL | W 28-14 vs. PIT | 15 | 81 | 5.4 | 0 | 20 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Ladd McConkey |
1. Ladd McConkey, WR | LAC | L 32-12 at HOU | 9 | 197 | 21.9 | 1 | 86 | 0 | |
| 2. Nico Collins, WR | HOU | W 32-12 vs. LAC | 7 | 122 | 17.4 | 1 | 41 | 0 | ||
| 3. Mike Evans, WR | TB | L 23-20 vs. WSH | 7 | 92 | 13.1 | 1 | 23 | 0 | ||
| 4. Terry McLaurin, WR | WSH | W 23-20 at TB | 7 | 89 | 12.7 | 1 | 35 | 0 | ||
| 5. Dyami Brown, WR | WSH | W 23-20 at TB | 5 | 89 | 17.8 | 1 | 30 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Elandon Roberts |
1. Elandon Roberts, LB | PIT | L 28-14 at BAL | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Reed Blankenship, S | PHI | W 22-10 vs. GB | 7 | 4 | 11 | 0.0 | 1 | 0 | 0 | |
| 3. Blake Cashman, LB | MIN | L 27-9 at LAR | 5 | 6 | 11 | 1.0 | 0 | 0 | 0 | |
| 4. Ivan Pace Jr., LB | MIN | L 27-9 at LAR | 7 | 3 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Daiyan Henley, LB | LAC | L 32-12 at HOU | 6 | 4 | 10 | 0.0 | 0 | 0 | 0 | |