| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Ben Roethlisberger |
1. Ben Roethlisberger, QB | PIT | L 45-42 vs. JAX | 37 | 58 | 469 | 5 | 1 | 2 | 1 | 110.5 |
| 2. Tom Brady, QB | NE | W 35-14 vs. TEN | 35 | 53 | 337 | 3 | 0 | 0 | 0 | 102.5 | |
| 3. Case Keenum, QB | MIN | W 29-24 vs. NO | 25 | 40 | 318 | 1 | 1 | 2 | 0 | 85.2 | |
| 4. Drew Brees, QB | NO | L 29-24 at MIN | 25 | 40 | 294 | 3 | 2 | 2 | 0 | 89.0 | |
| 5. Marcus Mariota, QB | TEN | L 35-14 at NE | 22 | 37 | 254 | 2 | 0 | 8 | 0 | 98.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Leonard Fournette |
1. Leonard Fournette, RB | JAX | W 45-42 at PIT | 25 | 109 | 4.4 | 3 | 18 | 0 | |
| 2. Tevin Coleman, RB | ATL | L 15-10 at PHI | 10 | 79 | 7.9 | 0 | 23 | 0 | ||
| 3. Le'Veon Bell, RB | PIT | L 45-42 vs. JAX | 16 | 67 | 4.2 | 1 | 21 | 0 | ||
| 4. Dion Lewis, RB | NE | W 35-14 vs. TEN | 15 | 62 | 4.1 | 0 | 10 | 0 | ||
| 5. Jay Ajayi, RB | PHI | W 15-10 vs. ATL | 15 | 54 | 3.6 | 0 | 11 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Stefon Diggs |
1. Stefon Diggs, WR | MIN | W 29-24 vs. NO | 6 | 137 | 22.8 | 1 | 61 | 0 | |
| 2. Antonio Brown, WR | PIT | L 45-42 vs. JAX | 7 | 132 | 18.9 | 2 | 43 | 0 | ||
| 3. Danny Amendola, WR | NE | W 35-14 vs. TEN | 11 | 112 | 10.2 | 0 | 25 | 0 | ||
| 4. Vance McDonald, TE | PIT | L 45-42 vs. JAX | 10 | 112 | 11.2 | 0 | 22 | 0 | ||
| 5. Julio Jones, WR | ATL | L 15-10 at PHI | 9 | 101 | 11.2 | 0 | 21 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Telvin Smith |
1. Telvin Smith, LB | JAX | W 45-42 at PIT | 14 | 2 | 16 | 0.0 | 0 | 0 | 1 |
| 2. Logan Ryan, S | TEN | L 35-14 at NE | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 3. Sean Davis, S | PIT | L 45-42 vs. JAX | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Wesley Woodyard, LB | TEN | L 35-14 at NE | 7 | 4 | 11 | 0.0 | 0 | 0 | 0 | |
| 5. Kevin Byard, S | TEN | L 35-14 at NE | 9 | 1 | 10 | 0.0 | 0 | 0 | 0 | |