| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Baker Mayfield |
1. Baker Mayfield, QB | TB | L 20-17 at MIA | 33 | 44 | 346 | 2 | 2 | 3 | 1 | 93.5 |
| 2. Tyler Shough, QB | NO | W 34-26 at TEN | 22 | 27 | 333 | 2 | 0 | 2 | 0 | 142.7 | |
| 3. Caleb Williams, QB | CHI | L 42-38 at SF | 25 | 42 | 330 | 2 | 0 | 0 | 0 | 100.3 | |
| 4. Dak Prescott, QB | DAL | W 30-23 at WSH | 19 | 37 | 307 | 2 | 0 | 6 | 0 | 97.5 | |
| 5. Joe Burrow, QB | CIN | W 37-14 vs. ARI | 24 | 31 | 305 | 2 | 0 | 3 | 0 | 129.1 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | BAL | W 41-24 at GB | 36 | 216 | 6.0 | 4 | 30 | 0 | |
| 2. Bijan Robinson, RB | ATL | W 27-24 vs. LAR | 22 | 195 | 8.9 | 1 | 93 | 0 | ||
| 3. Christian McCaffrey, RB | SF | W 42-38 vs. CHI | 23 | 140 | 6.1 | 1 | 41 | 0 | ||
| 4. Breece Hall, RB | NYJ | L 42-10 vs. NE | 14 | 111 | 7.9 | 1 | 59 | 0 | ||
| 5. Zach Charbonnet, RB | SEA | W 27-10 at CAR | 18 | 110 | 6.1 | 2 | 29 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Luther Burden III |
1. Luther Burden III, WR | CHI | L 42-38 at SF | 8 | 138 | 17.3 | 1 | 35 | 0 | |
| 2. Chris Olave, WR | NO | W 34-26 at TEN | 8 | 119 | 14.9 | 1 | 60 | 0 | ||
| 3. Parker Washington, WR | JAX | W 23-17 at IND | 8 | 115 | 14.4 | 0 | 37 | 0 | ||
| 4. Jalen McMillan, WR | TB | L 20-17 at MIA | 7 | 114 | 16.3 | 0 | 33 | 0 | ||
| 5. Wan'Dale Robinson, WR | NYG | W 34-10 at LV | 11 | 113 | 10.3 | 0 | 36 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Blake Cashman |
1. Blake Cashman, LB | MIN | W 23-10 vs. DET | 6 | 11 | 17 | 1.0 | 0 | 0 | 0 |
| 2. Cody Simon, LB | ARI | L 37-14 at CIN | 4 | 11 | 15 | 0.5 | 0 | 0 | 0 | |
| 3. Xavier McKinney, S | GB | L 41-24 vs. BAL | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Foyesade Oluokun, LB | JAX | W 23-17 at IND | 5 | 8 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Nick Cross, S | IND | L 23-17 vs. JAX | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |