| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Ben Roethlisberger |
1. Ben Roethlisberger, QB | PIT | L 48-37 vs. CLE | 47 | 68 | 501 | 4 | 4 | 0 | 0 | 85.5 |
| 2. Tom Brady, QB | TB | W 31-23 at WSH | 22 | 40 | 381 | 2 | 0 | 3 | 0 | 104.3 | |
| 3. Josh Allen, QB | BUF | W 27-24 vs. IND | 26 | 35 | 324 | 2 | 0 | 2 | 0 | 121.6 | |
| 4. Philip Rivers, QB | IND | L 27-24 at BUF | 27 | 46 | 309 | 2 | 0 | 0 | 0 | 93.5 | |
| 5. Taylor Heinicke, QB | WSH | L 31-23 vs. TB | 26 | 44 | 306 | 1 | 1 | 2 | 0 | 78.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Lamar Jackson |
1. Lamar Jackson, QB | BAL | W 20-13 at TEN | 16 | 136 | 8.5 | 1 | 48 | 0 | |
| 2. Cam Akers, RB | LAR | W 30-20 at SEA | 28 | 131 | 4.7 | 1 | 20 | 0 | ||
| 3. Alvin Kamara, RB | NO | W 21-9 vs. CHI | 23 | 99 | 4.3 | 1 | 25 | 0 | ||
| 4. Leonard Fournette, RB | TB | W 31-23 at WSH | 19 | 93 | 4.9 | 1 | 17 | 0 | ||
| 5. Jonathan Taylor, RB | IND | L 27-24 at BUF | 21 | 78 | 3.7 | 1 | 20 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
JuJu Smith-Schuster |
1. JuJu Smith-Schuster, WR | PIT | L 48-37 vs. CLE | 13 | 157 | 12.1 | 1 | 33 | 0 | |
| 2. Stefon Diggs, WR | BUF | W 27-24 vs. IND | 6 | 128 | 21.3 | 1 | 36 | 0 | ||
| 3. Mike Evans, WR | TB | W 31-23 at WSH | 6 | 119 | 19.8 | 0 | 35 | 0 | ||
| 4. Diontae Johnson, WR | PIT | L 48-37 vs. CLE | 11 | 117 | 10.6 | 0 | 19 | 0 | ||
| 5. Hollywood Brown, WR | BAL | W 20-13 at TEN | 7 | 109 | 15.6 | 0 | 28 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Bobby Wagner |
1. Bobby Wagner, LB | SEA | L 30-20 vs. LAR | 11 | 5 | 16 | 1.0 | 0 | 0 | 0 |
| 2. Shaquille Leonard, LB | IND | L 27-24 at BUF | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 3. Matt Milano, LB | BUF | W 27-24 vs. IND | 7 | 4 | 11 | 0.0 | 0 | 0 | 0 | |
| 4. M.J. Stewart, S | CLE | W 48-37 at PIT | 10 | 0 | 10 | 0.0 | 0 | 1 | 0 | |
| 5. Danny Trevathan, LB | CHI | L 21-9 at NO | 9 | 1 | 10 | 0.0 | 0 | 0 | 0 | |