| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matthew Stafford |
1. Matthew Stafford, QB | LAR | L 30-26 at DEN | 30 | 55 | 390 | 2 | 2 | 4 | 0 | 74.0 |
| 2. Sam Darnold, QB | SEA | L 33-31 at WSH | 31 | 45 | 379 | 4 | 2 | 0 | 0 | 105.7 | |
| 3. Geno Smith, QB | NYJ | L 31-24 at DET | 31 | 37 | 321 | 3 | 0 | 5 | 1 | 129.8 | |
| 4. Jordan Love, QB | GB | L 35-14 vs. ATL | 28 | 53 | 312 | 2 | 1 | 1 | 0 | 75.3 | |
| 5. Brock Purdy, QB | SF | W 36-30 vs. ARI | 15 | 27 | 297 | 4 | 0 | 0 | 0 | 133.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Bijan Robinson |
1. Bijan Robinson, RB | ATL | W 35-14 at GB | 29 | 194 | 6.7 | 2 | 55 | 0 | |
| 2. James Cook III, RB | BUF | W 24-16 vs. LAC | 24 | 154 | 6.4 | 1 | 23 | 1 | ||
| 3. Jaylen Warren, RB | PIT | W 30-27 vs. CIN | 17 | 127 | 7.5 | 0 | 35 | 0 | ||
| 4. Jahmyr Gibbs, RB | DET | W 31-24 vs. NYJ | 20 | 99 | 5.0 | 2 | 17 | 0 | ||
| 5. Javonte Williams, RB | DAL | L 34-31 vs. BAL | 19 | 98 | 5.2 | 1 | 22 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Drake London |
1. Drake London, WR | ATL | W 35-14 at GB | 9 | 194 | 21.6 | 0 | 68 | 0 | |
| 2. Davante Adams, WR | LAR | L 30-26 at DEN | 7 | 137 | 19.6 | 0 | 49 | 0 | ||
| 3. Jaxon Smith-Njigba, WR | SEA | L 33-31 at WSH | 10 | 128 | 12.8 | 2 | 26 | 0 | ||
| 4. Brock Bowers, TE | LV | W 35-27 at NO | 10 | 116 | 11.6 | 1 | 20 | 0 | ||
| 5. CeeDee Lamb, WR | DAL | L 34-31 vs. BAL | 7 | 112 | 16.0 | 0 | 49 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Fred Warner |
1. Fred Warner, LB | SF | W 36-30 vs. ARI | 7 | 10 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Arvell Reese, LB | NYG | W 12-7 vs. TEN | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Renardo Green, CB | SF | W 36-30 vs. ARI | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Patrick Queen, LB | PIT | W 30-27 vs. CIN | 4 | 9 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Nakobe Dean, LB | LV | W 35-27 at NO | 11 | 1 | 12 | 0.0 | 1 | 0 | 0 | |