| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Nick Mullens |
1. Nick Mullens, QB | MIN | L 30-24 vs. DET | 22 | 36 | 411 | 2 | 4 | 4 | 0 | 79.5 |
| 2. Joe Flacco, QB | CLE | W 36-22 at HOU | 27 | 42 | 368 | 3 | 2 | 0 | 0 | 96.1 | |
| 3. Jake Browning, QB | CIN | L 34-11 at PIT | 28 | 42 | 335 | 1 | 3 | 3 | 0 | 69.1 | |
| 4. Matthew Stafford, QB | LAR | W 30-22 vs. NO | 24 | 34 | 328 | 2 | 0 | 1 | 0 | 120.7 | |
| 5. Derek Carr, QB | NO | L 30-22 at LAR | 27 | 40 | 319 | 3 | 1 | 2 | 0 | 106.1 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Zamir White |
1. Zamir White, RB | LV | W 20-14 at KC | 22 | 145 | 6.6 | 0 | 43 | 0 | |
| 2. Aaron Jones Sr., RB | GB | W 33-30 at CAR | 21 | 127 | 6.0 | 0 | 39 | 0 | ||
| 3. Khalil Herbert, RB | CHI | W 27-16 vs. ARI | 20 | 112 | 5.6 | 1 | 15 | 0 | ||
| 4. Kyren Williams, RB | LAR | W 30-22 vs. NO | 22 | 104 | 4.7 | 1 | 10 | 0 | ||
| 5. Christian McCaffrey, RB | SF | L 33-19 vs. BAL | 14 | 103 | 7.4 | 1 | 39 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Amari Cooper |
1. Amari Cooper, WR | CLE | W 36-22 at HOU | 11 | 265 | 24.1 | 2 | 75 | 0 | |
| 2. George Pickens, WR | PIT | W 34-11 vs. CIN | 4 | 195 | 48.8 | 2 | 86 | 0 | ||
| 3. Puka Nacua, WR | LAR | W 30-22 vs. NO | 9 | 164 | 18.2 | 1 | 41 | 0 | ||
| 4. Justin Jefferson, WR | MIN | L 30-24 vs. DET | 6 | 141 | 23.5 | 1 | 29 | 0 | ||
| 5. Tee Higgins, WR | CIN | L 34-11 at PIT | 5 | 140 | 28.0 | 1 | 80 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Khaleke Hudson |
1. Khaleke Hudson, LB | WSH | L 30-28 at NYJ | 8 | 7 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Alex Singleton, LB | DEN | L 26-23 vs. NE | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 3. E.J. Speed, LB | IND | L 29-10 at ATL | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Donovan Wilson, S | DAL | L 22-20 at MIA | 8 | 4 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Foyesade Oluokun, LB | JAX | L 30-12 at TB | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |