| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Brock Purdy |
1. Brock Purdy, QB | SF | W 28-16 vs. SEA | 19 | 27 | 368 | 2 | 1 | 3 | 0 | 122.1 |
| 2. Desmond Ridder, QB | ATL | L 29-25 vs. TB | 26 | 40 | 347 | 1 | 1 | 3 | 0 | 90.3 | |
| 3. Will Levis, QB | TEN | W 28-27 at MIA | 23 | 38 | 327 | 1 | 1 | 1 | 1 | 86.2 | |
| 4. Lamar Jackson, QB | BAL | W 37-31 vs. LAR | 24 | 43 | 316 | 3 | 1 | 2 | 0 | 92.8 | |
| 5. Joe Flacco, QB | CLE | W 31-27 vs. JAX | 26 | 45 | 311 | 3 | 1 | 1 | 1 | 92.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Christian McCaffrey |
1. Christian McCaffrey, RB | SF | W 28-16 vs. SEA | 16 | 145 | 9.1 | 0 | 72 | 0 | |
| 2. Kyren Williams, RB | LAR | L 37-31 at BAL | 25 | 114 | 4.6 | 0 | 14 | 0 | ||
| 3. Rachaad White, RB | TB | W 29-25 at ATL | 25 | 102 | 4.1 | 0 | 12 | 0 | ||
| 4. Raheem Mostert, RB | MIA | L 28-27 vs. TEN | 21 | 96 | 4.6 | 2 | 15 | 0 | ||
| 5. Chuba Hubbard, RB | CAR | L 28-6 at NO | 23 | 87 | 3.8 | 0 | 13 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Drake London |
1. Drake London, WR | ATL | L 29-25 vs. TB | 10 | 172 | 17.2 | 0 | 45 | 0 | |
| 2. Deebo Samuel Sr., WR | SF | W 28-16 vs. SEA | 7 | 149 | 21.3 | 1 | 54 | 0 | ||
| 3. Brandon Aiyuk, WR | SF | W 28-16 vs. SEA | 6 | 126 | 21.0 | 0 | 45 | 1 | ||
| 4. DeAndre Hopkins, WR | TEN | W 28-27 at MIA | 7 | 124 | 17.7 | 1 | 45 | 0 | ||
| 5. Cooper Kupp, WR | LAR | L 37-31 at BAL | 8 | 115 | 14.4 | 1 | 34 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Jaquan Brisker |
1. Jaquan Brisker, S | CHI | W 28-13 vs. DET | 13 | 4 | 17 | 0.0 | 1 | 0 | 0 |
| 2. Jahlani Tavai, LB | NE | W 21-18 at PIT | 8 | 7 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Alex Singleton, LB | DEN | W 24-7 at LAC | 10 | 4 | 14 | 1.0 | 0 | 0 | 0 | |
| 4. Zaire Franklin, LB | IND | L 34-14 at CIN | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Ivan Pace Jr., LB | MIN | W 3-0 at LV | 7 | 6 | 13 | 1.0 | 0 | 1 | 0 | |