| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Trevor Lawrence |
1. Trevor Lawrence, QB | JAX | W 24-21 at HOU | 23 | 38 | 364 | 1 | 1 | 0 | 0 | 90.3 |
| 2. Josh Allen, QB | BUF | L 37-34 at PHI | 29 | 51 | 339 | 2 | 1 | 1 | 0 | 82.1 | |
| 3. Jared Goff, QB | DET | L 29-22 vs. GB | 29 | 44 | 332 | 2 | 0 | 3 | 3 | 103.6 | |
| 4. Dak Prescott, QB | DAL | W 45-10 vs. WSH | 22 | 32 | 331 | 4 | 0 | 0 | 0 | 142.1 | |
| 5. C.J. Stroud, QB | HOU | L 24-21 vs. JAX | 26 | 36 | 304 | 2 | 0 | 4 | 0 | 116.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Kyren Williams |
1. Kyren Williams, RB | LAR | W 37-14 at ARI | 16 | 143 | 8.9 | 0 | 56 | 0 | |
| 2. Christian McCaffrey, RB | SF | W 31-13 at SEA | 19 | 114 | 6.0 | 2 | 27 | 0 | ||
| 3. Josh Jacobs, RB | LV | L 31-17 vs. KC | 20 | 110 | 5.5 | 1 | 63 | 0 | ||
| 4. Rachaad White, RB | TB | L 27-20 at IND | 15 | 100 | 6.7 | 0 | 38 | 0 | ||
| 5. Najee Harris, RB | PIT | W 16-10 at CIN | 15 | 99 | 6.6 | 1 | 22 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Pat Freiermuth |
1. Pat Freiermuth, TE | PIT | W 16-10 at CIN | 9 | 120 | 13.3 | 0 | 29 | 0 | |
| 2. DJ Moore, WR | CHI | W 12-10 at MIN | 11 | 114 | 10.4 | 0 | 36 | 0 | ||
| 3. Jaylen Waddle, WR | MIA | W 34-13 at NYJ | 8 | 114 | 14.3 | 0 | 32 | 0 | ||
| 4. Chris Olave, WR | NO | L 24-15 at ATL | 7 | 114 | 16.3 | 0 | 51 | 0 | ||
| 5. Jalin Hyatt, WR | NYG | W 10-7 vs. NE | 5 | 109 | 21.8 | 0 | 41 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
C.J. Mosley |
1. C.J. Mosley, LB | NYJ | L 34-13 vs. MIA | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Kevin Byard, S | PHI | W 37-34 vs. BUF | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Jonathan Owens, S | GB | W 29-22 at DET | 8 | 4 | 12 | 0.0 | 0 | 0 | 1 | |
| 4. Jessie Bates III, S | ATL | W 24-15 vs. NO | 7 | 5 | 12 | 0.0 | 1 | 1 | 1 | |
| 5. Jordyn Brooks, LB | SEA | L 31-13 vs. SF | 7 | 5 | 12 | 0.0 | 0 | 1 | 1 | |