| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Sam Howell |
1. Sam Howell, QB | WSH | L 40-20 vs. CHI | 37 | 51 | 388 | 2 | 1 | 5 | 0 | 99.1 |
| 2. Josh Allen, QB | BUF | L 25-20 vs. JAX | 27 | 40 | 359 | 2 | 1 | 0 | 0 | 102.0 | |
| 3. Desmond Ridder, QB | ATL | W 21-19 vs. HOU | 28 | 37 | 329 | 1 | 0 | 0 | 0 | 111.2 | |
| 4. Joe Burrow, QB | CIN | W 34-20 at ARI | 36 | 46 | 317 | 3 | 1 | 3 | 0 | 108.1 | |
| 5. Trevor Lawrence, QB | JAX | W 25-20 at BUF | 25 | 37 | 315 | 1 | 0 | 5 | 2 | 102.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Breece Hall |
1. Breece Hall, RB | NYJ | W 31-21 at DEN | 22 | 177 | 8.0 | 1 | 72 | 0 | |
| 2. Zack Moss, RB | IND | W 23-16 vs. TEN | 23 | 165 | 7.2 | 2 | 56 | 0 | ||
| 3. De'Von Achane, RB | MIA | W 31-16 vs. NYG | 11 | 151 | 13.7 | 1 | 76 | 1 | ||
| 4. Travis Etienne Jr., RB | JAX | W 25-20 at BUF | 26 | 136 | 5.2 | 2 | 35 | 0 | ||
| 5. David Montgomery, RB | DET | W 42-24 vs. CAR | 19 | 109 | 5.7 | 1 | 42 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
DJ Moore |
1. DJ Moore, WR | CHI | W 40-20 at WSH | 8 | 230 | 28.8 | 3 | 58 | 0 | |
| 2. Ja'Marr Chase, WR | CIN | W 34-20 at ARI | 15 | 192 | 12.8 | 3 | 63 | 0 | ||
| 3. Tyreek Hill, WR | MIA | W 31-16 vs. NYG | 8 | 181 | 22.6 | 1 | 69 | 0 | ||
| 4. DeAndre Hopkins, WR | TEN | L 23-16 at IND | 8 | 140 | 17.5 | 0 | 36 | 0 | ||
| 5. George Pickens, WR | PIT | W 17-10 vs. BAL | 6 | 130 | 21.7 | 1 | 41 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Terrel Bernard |
1. Terrel Bernard, LB | BUF | L 25-20 vs. JAX | 8 | 8 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Ernest Jones IV, LB | LAR | L 23-14 vs. PHI | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Azeez Al-Shaair, LB | TEN | L 23-16 at IND | 7 | 8 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Jalen Pitre, S | HOU | L 21-19 at ATL | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. C.J. Mosley, LB | NYJ | W 31-21 at DEN | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |