| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Sam Howell |
1. Sam Howell, QB | WSH | L 38-31 vs. PHI | 39 | 52 | 397 | 4 | 1 | 1 | 0 | 114.0 |
| 2. Brock Purdy, QB | SF | L 31-17 vs. CIN | 22 | 31 | 365 | 1 | 2 | 2 | 1 | 94.2 | |
| 3. Josh Allen, QB | BUF | W 24-18 vs. TB | 31 | 40 | 324 | 2 | 1 | 2 | 0 | 106.7 | |
| 4. Tua Tagovailoa, QB | MIA | W 31-17 vs. NE | 30 | 45 | 324 | 3 | 1 | 2 | 1 | 100.6 | |
| 5. Jalen Hurts, QB | PHI | W 38-31 at WSH | 29 | 38 | 319 | 4 | 0 | 2 | 1 | 135.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jahmyr Gibbs |
1. Jahmyr Gibbs, RB | DET | W 26-14 vs. LV | 26 | 152 | 5.8 | 1 | 27 | 0 | |
| 2. Saquon Barkley, RB | NYG | L 13-10 vs. NYJ | 36 | 128 | 3.6 | 0 | 34 | 0 | ||
| 3. Derrick Henry, RB | TEN | W 28-23 vs. ATL | 22 | 101 | 4.6 | 0 | 14 | 0 | ||
| 4. Jonathan Taylor, RB | IND | L 38-27 vs. NO | 12 | 95 | 7.9 | 0 | 42 | 0 | ||
| 5. Joe Mixon, RB | CIN | W 31-17 at SF | 16 | 87 | 5.4 | 1 | 20 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
CeeDee Lamb |
1. CeeDee Lamb, WR | DAL | W 43-20 vs. LAR | 12 | 158 | 13.2 | 2 | 26 | 0 | |
| 2. Rashid Shaheed, WR | NO | W 38-27 at IND | 3 | 153 | 51.0 | 1 | 58 | 0 | ||
| 3. George Kittle, TE | SF | L 31-17 vs. CIN | 9 | 149 | 16.6 | 0 | 34 | 0 | ||
| 4. A.J. Brown, WR | PHI | W 38-31 at WSH | 8 | 130 | 16.3 | 2 | 25 | 0 | ||
| 5. DeAndre Hopkins, WR | TEN | W 28-23 vs. ATL | 4 | 128 | 32.0 | 3 | 61 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
De'Vondre Campbell |
1. De'Vondre Campbell, LB | GB | L 24-10 vs. MIN | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Lavonte David, LB | TB | L 24-18 at BUF | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Zaire Franklin, LB | IND | L 38-27 vs. NO | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Nakobe Dean, LB | PHI | W 38-31 at WSH | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Ryan Neal, S | TB | L 24-18 at BUF | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |