| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Dak Prescott |
1. Dak Prescott, QB | DAL | W 20-19 vs. DET | 26 | 38 | 345 | 2 | 1 | 3 | 0 | 103.5 |
| 2. Lamar Jackson, QB | BAL | W 56-19 vs. MIA | 18 | 21 | 321 | 5 | 0 | 1 | 0 | 158.3 | |
| 3. Tyrod Taylor, QB | NYG | L 26-25 vs. LAR | 27 | 41 | 319 | 1 | 1 | 6 | 0 | 87.3 | |
| 4. Matthew Stafford, QB | LAR | W 26-25 at NYG | 24 | 34 | 317 | 1 | 2 | 4 | 0 | 85.1 | |
| 5. Joe Flacco, QB | CLE | W 37-20 vs. NYJ | 19 | 29 | 309 | 3 | 1 | 1 | 0 | 121.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Isiah Pacheco |
1. Isiah Pacheco, RB | KC | W 25-17 vs. CIN | 18 | 130 | 7.2 | 0 | 37 | 0 | |
| 2. James Conner, RB | ARI | W 35-31 at PHI | 26 | 128 | 4.9 | 1 | 22 | 0 | ||
| 3. Khalil Herbert, RB | CHI | W 37-17 vs. ATL | 18 | 124 | 6.9 | 1 | 38 | 0 | ||
| 4. Najee Harris, RB | PIT | W 30-23 at SEA | 27 | 122 | 4.5 | 2 | 23 | 0 | ||
| 5. Aaron Jones Sr., RB | GB | W 33-10 at MIN | 20 | 120 | 6.0 | 0 | 25 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
CeeDee Lamb |
1. CeeDee Lamb, WR | DAL | W 20-19 vs. DET | 13 | 227 | 17.5 | 1 | 92 | 1 | |
| 2. DJ Moore, WR | CHI | W 37-17 vs. ATL | 9 | 159 | 17.7 | 1 | 32 | 0 | ||
| 3. David Njoku, TE | CLE | W 37-20 vs. NYJ | 6 | 134 | 22.3 | 0 | 43 | 1 | ||
| 4. George Pickens, WR | PIT | W 30-23 at SEA | 7 | 131 | 18.7 | 0 | 37 | 0 | ||
| 5. Rashee Rice, WR | KC | W 25-17 vs. CIN | 5 | 127 | 25.4 | 0 | 67 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Devin Bush |
1. Devin Bush, LB | SEA | L 30-23 vs. PIT | 5 | 13 | 18 | 0.0 | 0 | 0 | 0 |
| 2. Sione Takitaki, LB | CLE | W 37-20 vs. NYJ | 11 | 5 | 16 | 0.0 | 0 | 0 | 0 | |
| 3. Julian Love, S | SEA | L 30-23 vs. PIT | 10 | 4 | 14 | 0.0 | 1 | 0 | 0 | |
| 4. Nicholas Morrow, LB | PHI | L 35-31 vs. ARI | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Eric Kendricks, LB | LAC | L 16-9 at DEN | 5 | 9 | 14 | 0.0 | 0 | 0 | 0 | |