| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jake Browning |
1. Jake Browning, QB | CIN | W 34-31 at JAX | 32 | 37 | 354 | 1 | 0 | 2 | 0 | 115.5 |
| 2. Geno Smith, QB | SEA | L 41-35 at DAL | 23 | 41 | 334 | 3 | 1 | 0 | 0 | 97.0 | |
| 3. Brock Purdy, QB | SF | W 42-19 at PHI | 19 | 27 | 314 | 4 | 0 | 2 | 0 | 148.8 | |
| 4. Gardner Minshew II, QB | IND | W 31-28 at TEN | 26 | 42 | 312 | 2 | 0 | 3 | 1 | 100.5 | |
| 5. Dak Prescott, QB | DAL | W 41-35 vs. SEA | 29 | 41 | 299 | 3 | 0 | 4 | 0 | 115.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Isiah Pacheco |
1. Isiah Pacheco, RB | KC | L 27-19 at GB | 18 | 110 | 6.1 | 1 | 26 | 0 | |
| 2. James Conner, RB | ARI | W 24-10 at PIT | 25 | 105 | 4.2 | 2 | 29 | 0 | ||
| 3. Chuba Hubbard, RB | CAR | L 21-18 at TB | 25 | 104 | 4.2 | 2 | 17 | 0 | ||
| 4. Derrick Henry, RB | TEN | L 31-28 vs. IND | 21 | 102 | 4.9 | 2 | 22 | 0 | ||
| 5. Christian McCaffrey, RB | SF | W 42-19 at PHI | 17 | 93 | 5.5 | 1 | 16 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Nico Collins |
1. Nico Collins, WR | HOU | W 22-17 vs. DEN | 9 | 191 | 21.2 | 1 | 59 | 0 | |
| 2. Mike Evans, WR | TB | W 21-18 vs. CAR | 7 | 162 | 23.1 | 1 | 75 | 0 | ||
| 3. Tyreek Hill, WR | MIA | W 45-15 at WSH | 5 | 157 | 31.4 | 2 | 78 | 0 | ||
| 4. Ja'Marr Chase, WR | CIN | W 34-31 at JAX | 11 | 149 | 13.5 | 1 | 76 | 0 | ||
| 5. Sam LaPorta, TE | DET | W 33-28 at NO | 9 | 140 | 15.6 | 1 | 48 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Ernest Jones IV |
1. Ernest Jones IV, LB | LAR | W 36-19 vs. CLE | 6 | 9 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Bobby Wagner, LB | SEA | L 41-35 at DAL | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Jack Gibbens, LB | TEN | L 31-28 vs. IND | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Foyesade Oluokun, LB | JAX | L 34-31 vs. CIN | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Quay Walker, LB | GB | W 27-19 vs. KC | 4 | 9 | 13 | 0.0 | 0 | 0 | 0 | |