| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
C.J. Stroud |
1. C.J. Stroud, QB | HOU | W 21-16 vs. ARI | 27 | 37 | 336 | 2 | 3 | 3 | 0 | 85.0 |
| 2. Brock Purdy, QB | SF | W 27-14 vs. TB | 21 | 25 | 333 | 3 | 0 | 4 | 0 | 158.3 | |
| 3. Tua Tagovailoa, QB | MIA | W 20-13 vs. LV | 28 | 39 | 325 | 2 | 1 | 1 | 1 | 103.1 | |
| 4. Jordan Love, QB | GB | W 23-20 vs. LAC | 27 | 40 | 322 | 2 | 0 | 3 | 0 | 108.5 | |
| 5. Josh Allen, QB | BUF | W 32-6 vs. NYJ | 20 | 32 | 275 | 3 | 1 | 1 | 0 | 108.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jaylen Warren |
1. Jaylen Warren, RB | PIT | L 13-10 at CLE | 9 | 129 | 14.3 | 1 | 74 | 0 | |
| 2. Devin Singletary, RB | HOU | W 21-16 vs. ARI | 22 | 112 | 5.1 | 1 | 21 | 0 | ||
| 3. Justin Fields, QB | CHI | L 31-26 at DET | 18 | 104 | 5.8 | 0 | 29 | 0 | ||
| 4. Isiah Pacheco, RB | KC | L 21-17 vs. PHI | 19 | 89 | 4.7 | 0 | 24 | 0 | ||
| 5. Raheem Mostert, RB | MIA | W 20-13 vs. LV | 22 | 86 | 3.9 | 0 | 10 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Brandon Aiyuk |
1. Brandon Aiyuk, WR | SF | W 27-14 vs. TB | 5 | 156 | 31.2 | 1 | 76 | 0 | |
| 2. Tank Dell, WR | HOU | W 21-16 vs. ARI | 8 | 149 | 18.6 | 1 | 40 | 0 | ||
| 3. Tyreek Hill, WR | MIA | W 20-13 vs. LV | 10 | 146 | 14.6 | 1 | 38 | 0 | ||
| 4. Keenan Allen, WR | LAC | L 23-20 at GB | 10 | 116 | 11.6 | 1 | 38 | 0 | ||
| 5. Odell Beckham Jr., WR | BAL | W 34-20 vs. CIN | 4 | 116 | 29.0 | 0 | 51 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Blake Cashman |
1. Blake Cashman, LB | HOU | W 21-16 vs. ARI | 13 | 6 | 19 | 1.0 | 0 | 0 | 0 |
| 2. Alex Singleton, LB | DEN | W 21-20 vs. MIN | 11 | 5 | 16 | 0.0 | 0 | 0 | 0 | |
| 3. Antoine Winfield Jr., S | TB | L 27-14 at SF | 9 | 7 | 16 | 0.0 | 0 | 0 | 0 | |
| 4. Elandon Roberts, LB | PIT | L 13-10 at CLE | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |
| 5. Alex Anzalone, LB | DET | W 31-26 vs. CHI | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |