| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Justin Fields |
1. Justin Fields, QB | CHI | L 31-28 vs. DEN | 28 | 35 | 335 | 4 | 1 | 4 | 1 | 132.7 |
| 2. Josh Allen, QB | BUF | W 48-20 vs. MIA | 21 | 25 | 320 | 4 | 0 | 2 | 0 | 158.3 | |
| 3. Jalen Hurts, QB | PHI | W 34-31 vs. WSH | 25 | 37 | 319 | 2 | 0 | 3 | 0 | 112.3 | |
| 4. Matthew Stafford, QB | LAR | W 29-23 at IND | 27 | 40 | 319 | 1 | 1 | 2 | 0 | 89.5 | |
| 5. C.J. Stroud, QB | HOU | W 30-6 vs. PIT | 16 | 30 | 306 | 2 | 0 | 0 | 0 | 111.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 27-3 vs. CIN | 22 | 122 | 5.5 | 1 | 29 | 0 | |
| 2. David Montgomery, RB | DET | W 34-20 at GB | 32 | 121 | 3.8 | 3 | 16 | 0 | ||
| 3. Isiah Pacheco, RB | KC | W 23-20 at NYJ | 20 | 115 | 5.8 | 1 | 48 | 0 | ||
| 4. Christian McCaffrey, RB | SF | W 35-16 vs. ARI | 20 | 106 | 5.3 | 3 | 18 | 0 | ||
| 5. Bijan Robinson, RB | ATL | L 23-7 at JAX | 14 | 105 | 7.5 | 0 | 38 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
A.J. Brown |
1. A.J. Brown, WR | PHI | W 34-31 vs. WSH | 9 | 175 | 19.4 | 2 | 59 | 0 | |
| 2. Nico Collins, WR | HOU | W 30-6 vs. PIT | 7 | 168 | 24.0 | 2 | 52 | 0 | ||
| 3. Puka Nacua, WR | LAR | W 29-23 at IND | 9 | 163 | 18.1 | 1 | 32 | 0 | ||
| 4. Brandon Aiyuk, WR | SF | W 35-16 vs. ARI | 6 | 148 | 24.7 | 0 | 42 | 0 | ||
| 5. DJ Moore, WR | CHI | L 31-28 vs. DEN | 8 | 131 | 16.4 | 1 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Quay Walker |
1. Quay Walker, LB | GB | L 34-20 vs. DET | 10 | 9 | 19 | 0.0 | 0 | 0 | 0 |
| 2. Bobby Wagner, LB | SEA | W 24-3 at NYG | 9 | 8 | 17 | 2.0 | 0 | 0 | 0 | |
| 3. Kyle Dugger, S | NE | L 38-3 at DAL | 12 | 3 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Harrison Smith, S | MIN | W 21-13 at CAR | 8 | 6 | 14 | 3.0 | 1 | 0 | 0 | |
| 5. Quincy Williams, LB | NYJ | L 23-20 vs. KC | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |