| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
C.J. Stroud |
1. C.J. Stroud, QB | HOU | W 39-37 vs. TB | 30 | 42 | 470 | 5 | 0 | 3 | 0 | 147.8 |
| 2. Dak Prescott, QB | DAL | L 28-23 at PHI | 29 | 44 | 374 | 3 | 0 | 5 | 0 | 115.2 | |
| 3. Joe Burrow, QB | CIN | W 24-18 vs. BUF | 31 | 44 | 348 | 2 | 0 | 1 | 0 | 108.9 | |
| 4. Sam Howell, QB | WSH | W 20-17 at NE | 29 | 45 | 325 | 1 | 1 | 3 | 0 | 84.0 | |
| 5. Taylor Heinicke, QB | ATL | L 31-28 vs. MIN | 21 | 38 | 268 | 1 | 1 | 1 | 0 | 75.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Keaton Mitchell |
1. Keaton Mitchell, RB | BAL | W 37-3 vs. SEA | 9 | 138 | 15.3 | 1 | 60 | 0 | |
| 2. Josh Jacobs, RB | LV | W 30-6 vs. NYG | 26 | 98 | 3.8 | 2 | 15 | 0 | ||
| 3. Saquon Barkley, RB | NYG | L 30-6 at LV | 16 | 90 | 5.6 | 0 | 26 | 0 | ||
| 4. Jaylen Warren, RB | PIT | W 20-16 vs. TEN | 11 | 88 | 8.0 | 0 | 22 | 0 | ||
| 5. Rhamondre Stevenson, RB | NE | L 20-17 vs. WSH | 9 | 87 | 9.7 | 1 | 64 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
CeeDee Lamb |
1. CeeDee Lamb, WR | DAL | L 28-23 at PHI | 11 | 191 | 17.4 | 0 | 29 | 1 | |
| 2. Noah Brown, WR | HOU | W 39-37 vs. TB | 6 | 153 | 25.5 | 1 | 75 | 0 | ||
| 3. Amari Cooper, WR | CLE | W 27-0 vs. ARI | 5 | 139 | 27.8 | 1 | 59 | 0 | ||
| 4. Dalton Schultz, TE | HOU | W 39-37 vs. TB | 10 | 130 | 13.0 | 1 | 26 | 1 | ||
| 5. Tank Dell, WR | HOU | W 39-37 vs. TB | 6 | 114 | 19.0 | 2 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
T.J. Edwards |
1. T.J. Edwards, LB | CHI | L 24-17 at NO | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Ja'Whaun Bentley, LB | NE | L 20-17 vs. WSH | 10 | 3 | 13 | 2.0 | 0 | 0 | 0 | |
| 3. Lavonte David, LB | TB | L 39-37 at HOU | 9 | 2 | 11 | 0.0 | 1 | 0 | 0 | |
| 4. Jordan Hicks, LB | MIN | W 31-28 at ATL | 9 | 2 | 11 | 1.0 | 0 | 0 | 0 | |
| 5. Jordan Poyer, S | BUF | L 24-18 at CIN | 8 | 3 | 11 | 0.0 | 0 | 0 | 0 | |