| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jared Goff |
1. Jared Goff, QB | DET | L 34-31 at SF | 25 | 41 | 273 | 1 | 0 | 2 | 0 | 88.8 |
| 2. Lamar Jackson, QB | BAL | L 17-10 vs. KC | 20 | 37 | 272 | 1 | 1 | 4 | 1 | 75.5 | |
| 3. Brock Purdy, QB | SF | W 34-31 vs. DET | 20 | 31 | 267 | 1 | 1 | 2 | 0 | 89.0 | |
| 4. Patrick Mahomes, QB | KC | W 17-10 at BAL | 30 | 39 | 241 | 1 | 0 | 2 | 0 | 100.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
David Montgomery |
1. David Montgomery, RB | DET | L 34-31 at SF | 15 | 93 | 6.2 | 1 | 16 | 0 | |
| 2. Christian McCaffrey, RB | SF | W 34-31 vs. DET | 20 | 90 | 4.5 | 2 | 25 | 0 | ||
| 3. Isiah Pacheco, RB | KC | W 17-10 at BAL | 24 | 68 | 2.8 | 1 | 12 | 0 | ||
| 4. Lamar Jackson, QB | BAL | L 17-10 vs. KC | 8 | 54 | 6.8 | 0 | 21 | 1 | ||
| 5. Brock Purdy, QB | SF | W 34-31 vs. DET | 5 | 48 | 9.6 | 0 | 21 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Travis Kelce |
1. Travis Kelce, TE | KC | W 17-10 at BAL | 11 | 116 | 10.5 | 1 | 21 | 0 | |
| 2. Zay Flowers, WR | BAL | L 17-10 vs. KC | 5 | 115 | 23.0 | 1 | 54 | 1 | ||
| 3. Sam LaPorta, TE | DET | L 34-31 at SF | 9 | 97 | 10.8 | 0 | 16 | 0 | ||
| 4. Deebo Samuel, WR | SF | W 34-31 vs. DET | 8 | 89 | 11.1 | 0 | 26 | 0 | ||
| 5. Amon-Ra St. Brown, WR | DET | L 34-31 at SF | 7 | 87 | 12.4 | 0 | 23 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Roquan Smith |
1. Roquan Smith, LB | BAL | L 17-10 vs. KC | 5 | 11 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Fred Warner, LB | SF | W 34-31 vs. DET | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Kyle Hamilton, S | BAL | L 17-10 vs. KC | 9 | 2 | 11 | 0.0 | 0 | 0 | 0 | |
| 4. Ji'Ayir Brown, S | SF | W 34-31 vs. DET | 5 | 5 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Alex Anzalone, LB | DET | L 34-31 at SF | 8 | 1 | 9 | 0.0 | 0 | 0 | 0 | |