| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
C.J. Stroud |
1. C.J. Stroud, QB | HOU | L 31-20 vs. IND | 30 | 47 | 384 | 2 | 0 | 6 | 1 | 103.5 |
| 2. Kirk Cousins, QB | MIN | L 34-28 at PHI | 31 | 44 | 364 | 4 | 0 | 2 | 1 | 125.6 | |
| 3. Geno Smith, QB | SEA | W 37-31 at DET | 32 | 41 | 328 | 2 | 0 | 1 | 0 | 116.3 | |
| 4. Jared Goff, QB | DET | L 37-31 vs. SEA | 28 | 35 | 323 | 3 | 1 | 2 | 0 | 121.8 | |
| 5. Daniel Jones, QB | NYG | W 31-28 at ARI | 26 | 37 | 321 | 2 | 1 | 3 | 0 | 103.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
D'Andre Swift |
1. D'Andre Swift, RB | PHI | W 34-28 vs. MIN | 28 | 175 | 6.3 | 1 | 43 | 0 | |
| 2. Bijan Robinson, RB | ATL | W 25-24 vs. GB | 19 | 124 | 6.5 | 0 | 19 | 0 | ||
| 3. James Cook III, RB | BUF | W 38-10 vs. LV | 17 | 123 | 7.2 | 0 | 36 | 0 | ||
| 4. Raheem Mostert, RB | MIA | W 24-17 at NE | 18 | 121 | 6.7 | 2 | 43 | 0 | ||
| 5. Christian McCaffrey, RB | SF | W 30-23 at LAR | 20 | 116 | 5.8 | 1 | 51 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Mike Evans |
1. Mike Evans, WR | TB | W 27-17 vs. CHI | 6 | 171 | 28.5 | 1 | 70 | 0 | |
| 2. Justin Jefferson, WR | MIN | L 34-28 at PHI | 11 | 159 | 14.5 | 0 | 30 | 1 | ||
| 3. Puka Nacua, WR | LAR | L 30-23 vs. SF | 15 | 147 | 9.8 | 0 | 20 | 0 | ||
| 4. Nico Collins, WR | HOU | L 31-20 vs. IND | 7 | 146 | 20.9 | 1 | 32 | 0 | ||
| 5. CeeDee Lamb, WR | DAL | W 30-10 vs. NYJ | 11 | 143 | 13.0 | 0 | 31 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Quay Walker |
1. Quay Walker, LB | GB | L 25-24 at ATL | 8 | 9 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Tremaine Edmunds, LB | CHI | L 27-17 at TB | 8 | 7 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Cam Bynum, S | MIN | L 34-28 at PHI | 6 | 9 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Robert Spillane, LB | LV | L 38-10 at BUF | 8 | 6 | 14 | 1.0 | 0 | 0 | 0 | |
| 5. De'Vondre Campbell, LB | GB | L 25-24 at ATL | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |