| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Nick Mullens |
1. Nick Mullens, QB | MIN | L 30-20 at DET | 30 | 44 | 396 | 2 | 2 | 4 | 0 | 92.6 |
| 2. Josh Allen, QB | BUF | W 21-14 at MIA | 30 | 38 | 359 | 2 | 2 | 3 | 1 | 101.7 | |
| 3. Jared Goff, QB | DET | W 30-20 vs. MIN | 23 | 32 | 320 | 2 | 0 | 1 | 0 | 124.5 | |
| 4. Jordan Love, QB | GB | W 17-9 vs. CHI | 27 | 32 | 316 | 2 | 0 | 1 | 1 | 128.6 | |
| 5. Tyrod Taylor, QB | NYG | W 27-10 vs. PHI | 23 | 32 | 297 | 1 | 1 | 1 | 0 | 98.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jonathan Taylor |
1. Jonathan Taylor, RB | IND | L 23-19 vs. HOU | 30 | 188 | 6.3 | 1 | 49 | 0 | |
| 2. Breece Hall, RB | NYJ | W 17-3 at NE | 37 | 178 | 4.8 | 1 | 50 | 0 | ||
| 3. Derrick Henry, RB | TEN | W 28-20 vs. JAX | 19 | 153 | 8.1 | 1 | 69 | 0 | ||
| 4. James Conner, RB | ARI | L 21-20 vs. SEA | 27 | 150 | 5.6 | 1 | 29 | 0 | ||
| 5. Zamir White, RB | LV | W 27-14 vs. DEN | 25 | 112 | 4.5 | 0 | 25 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Nico Collins |
1. Nico Collins, WR | HOU | W 23-19 at IND | 9 | 195 | 21.7 | 1 | 75 | 0 | |
| 2. Justin Jefferson, WR | MIN | L 30-20 at DET | 12 | 192 | 16.0 | 1 | 38 | 0 | ||
| 3. Amon-Ra St. Brown, WR | DET | W 30-20 vs. MIN | 7 | 144 | 20.6 | 1 | 70 | 0 | ||
| 4. Jayden Reed, WR | GB | W 17-9 vs. CHI | 4 | 112 | 28.0 | 0 | 59 | 0 | ||
| 5. Calvin Ridley, WR | JAX | L 28-20 at TEN | 6 | 106 | 17.7 | 1 | 59 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Bobby Wagner |
1. Bobby Wagner, LB | SEA | W 21-20 at ARI | 4 | 11 | 15 | 0.0 | 0 | 0 | 0 |
| 2. E.J. Speed, LB | IND | L 23-19 vs. HOU | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Khaleke Hudson, LB | WSH | L 38-10 vs. DAL | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Del'Shawn Phillips, LB | BAL | L 17-10 vs. PIT | 8 | 5 | 13 | 0.0 | 1 | 0 | 0 | |
| 5. Alex Singleton, LB | DEN | L 27-14 at LV | 5 | 8 | 13 | 0.0 | 0 | 0 | 0 | |