| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jared Goff |
1. Jared Goff, QB | DET | W 20-6 at TB | 30 | 44 | 353 | 2 | 0 | 3 | 0 | 107.5 |
| 2. Derek Carr, QB | NO | L 20-13 at HOU | 32 | 50 | 353 | 1 | 1 | 2 | 0 | 83.2 | |
| 3. Gardner Minshew II, QB | IND | L 37-20 at JAX | 33 | 55 | 329 | 1 | 3 | 3 | 1 | 60.4 | |
| 4. Geno Smith, QB | SEA | L 17-13 at CIN | 27 | 41 | 326 | 0 | 2 | 4 | 0 | 69.8 | |
| 5. Desmond Ridder, QB | ATL | L 24-16 vs. WSH | 28 | 47 | 307 | 2 | 3 | 3 | 0 | 66.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Kyren Williams |
1. Kyren Williams, RB | LAR | W 26-9 vs. ARI | 20 | 158 | 7.9 | 1 | 31 | 0 | |
| 2. Raheem Mostert, RB | MIA | W 42-21 vs. CAR | 17 | 115 | 6.8 | 2 | 49 | 0 | ||
| 3. Derrick Henry, RB | TEN | L 24-16 vs. BAL | 12 | 97 | 8.1 | 1 | 63 | 0 | ||
| 4. Saquon Barkley, RB | NYG | L 14-9 at BUF | 24 | 93 | 3.9 | 0 | 34 | 0 | ||
| 5. Chuba Hubbard, RB | CAR | L 42-21 at MIA | 19 | 88 | 4.6 | 1 | 19 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tyreek Hill |
1. Tyreek Hill, WR | MIA | W 42-21 vs. CAR | 6 | 163 | 27.2 | 1 | 47 | 0 | |
| 2. Cooper Kupp, WR | LAR | W 26-9 vs. ARI | 7 | 148 | 21.1 | 1 | 49 | 0 | ||
| 3. A.J. Brown, WR | PHI | L 20-14 at NYJ | 7 | 131 | 18.7 | 0 | 49 | 0 | ||
| 4. Drake London, WR | ATL | L 24-16 vs. WSH | 9 | 125 | 13.9 | 0 | 32 | 0 | ||
| 5. Amon-Ra St. Brown, WR | DET | W 20-6 at TB | 12 | 124 | 10.3 | 1 | 27 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Foyesade Oluokun |
1. Foyesade Oluokun, LB | JAX | W 37-20 vs. IND | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Taron Johnson, CB | BUF | W 14-9 vs. NYG | 9 | 6 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Blake Cashman, LB | HOU | W 20-13 vs. NO | 9 | 6 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Azeez Al-Shaair, LB | TEN | L 24-16 vs. BAL | 9 | 6 | 15 | 0.0 | 0 | 0 | 0 | |
| 5. Cody Barton, LB | WSH | W 24-16 at ATL | 5 | 10 | 15 | 0.0 | 0 | 0 | 0 | |