| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | W 31-17 vs. LAC | 32 | 42 | 424 | 4 | 1 | 1 | 0 | 129.5 |
| 2. Kirk Cousins, QB | MIN | W 22-17 vs. SF | 35 | 45 | 378 | 2 | 1 | 0 | 0 | 107.2 | |
| 3. Lamar Jackson, QB | BAL | W 38-6 vs. DET | 21 | 27 | 357 | 3 | 0 | 0 | 1 | 155.8 | |
| 4. Gardner Minshew II, QB | IND | L 39-38 vs. CLE | 15 | 23 | 305 | 2 | 1 | 4 | 3 | 119.4 | |
| 5. Derek Carr, QB | NO | L 31-24 vs. JAX | 33 | 55 | 301 | 1 | 1 | 1 | 0 | 73.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Kenneth Walker III |
1. Kenneth Walker III, RB | SEA | W 20-10 vs. ARI | 26 | 105 | 4.0 | 0 | 25 | 0 | |
| 2. D'Onta Foreman, RB | CHI | W 30-12 vs. LV | 16 | 89 | 5.6 | 2 | 14 | 0 | ||
| 3. Javonte Williams, RB | DEN | W 19-17 vs. GB | 15 | 82 | 5.5 | 0 | 21 | 0 | ||
| 4. Saquon Barkley, RB | NYG | W 14-7 vs. WSH | 21 | 77 | 3.7 | 0 | 12 | 1 | ||
| 5. Joshua Kelley, RB | LAC | L 31-17 at KC | 7 | 75 | 10.7 | 1 | 49 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Travis Kelce |
1. Travis Kelce, TE | KC | W 31-17 vs. LAC | 12 | 179 | 14.9 | 1 | 53 | 0 | |
| 2. Puka Nacua, WR | LAR | L 24-17 vs. PIT | 8 | 154 | 19.3 | 0 | 36 | 0 | ||
| 3. A.J. Brown, WR | PHI | W 31-17 vs. MIA | 10 | 137 | 13.7 | 1 | 42 | 0 | ||
| 4. Joshua Palmer, WR | LAC | L 31-17 at KC | 5 | 133 | 26.6 | 0 | 60 | 0 | ||
| 5. Josh Downs, WR | IND | L 39-38 vs. CLE | 5 | 125 | 25.0 | 1 | 59 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Foyesade Oluokun |
1. Foyesade Oluokun, LB | JAX | W 31-24 at NO | 9 | 5 | 14 | 0.0 | 0 | 1 | 1 |
| 2. Lavonte David, LB | TB | L 16-13 vs. ATL | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Fred Warner, LB | SF | L 22-17 at MIN | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Dean Marlowe, S | LAC | L 31-17 at KC | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Nate Landman, LB | ATL | W 16-13 at TB | 5 | 7 | 12 | 0.0 | 1 | 0 | 0 | |