| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Ryan Fitzpatrick |
1. Ryan Fitzpatrick, QB | MIA | W 38-35 vs. CIN | 31 | 52 | 419 | 4 | 1 | 2 | 0 | 103.0 |
| 2. Andy Dalton, QB | CIN | L 38-35 at MIA | 33 | 56 | 396 | 4 | 0 | 4 | 1 | 104.5 | |
| 3. Matt Ryan, QB | ATL | W 24-12 vs. JAX | 32 | 45 | 384 | 1 | 2 | 1 | 0 | 85.8 | |
| 4. Daniel Jones, QB | NYG | W 41-35 at WSH | 28 | 42 | 352 | 5 | 0 | 1 | 0 | 132.1 | |
| 5. Jameis Winston, QB | TB | L 23-20 vs. HOU | 25 | 48 | 335 | 1 | 4 | 3 | 0 | 46.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Saquon Barkley |
1. Saquon Barkley, RB | NYG | W 41-35 at WSH | 22 | 189 | 8.6 | 1 | 67 | 0 | |
| 2. Kenyan Drake, RB | ARI | W 27-13 at SEA | 24 | 166 | 6.9 | 2 | 80 | 0 | ||
| 3. Aaron Jones Sr., RB | GB | W 23-10 at MIN | 23 | 154 | 6.7 | 2 | 56 | 1 | ||
| 4. Phillip Lindsay, RB | DEN | W 27-17 vs. DET | 19 | 109 | 5.7 | 1 | 27 | 0 | ||
| 5. Lamar Jackson, QB | BAL | W 31-15 at CLE | 17 | 103 | 6.1 | 0 | 15 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Julio Jones |
1. Julio Jones, WR | ATL | W 24-12 vs. JAX | 10 | 166 | 16.6 | 0 | 32 | 0 | |
| 2. Michael Thomas, WR | NO | W 38-28 at TEN | 12 | 136 | 11.3 | 1 | 26 | 0 | ||
| 3. Tyler Boyd, WR | CIN | L 38-35 at MIA | 9 | 128 | 14.2 | 2 | 34 | 0 | ||
| 4. Christian McCaffrey, RB | CAR | L 38-6 at IND | 15 | 119 | 7.9 | 0 | 13 | 0 | ||
| 5. Robert Woods, WR | LAR | L 34-31 at SF | 8 | 117 | 14.6 | 0 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Sean Lee |
1. Sean Lee, LB | DAL | L 17-9 at PHI | 9 | 8 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Donald Payne, LB | JAX | L 24-12 at ATL | 9 | 7 | 16 | 0.0 | 0 | 0 | 0 | |
| 3. Dre Greenlaw, LB | SF | W 34-31 vs. LAR | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Shawn Williams, S | CIN | L 38-35 at MIA | 8 | 5 | 13 | 1.0 | 0 | 0 | 0 | |
| 5. Bobby Wagner, LB | SEA | L 27-13 vs. ARI | 7 | 6 | 13 | 1.0 | 0 | 0 | 0 | |