| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matt Schaub |
1. Matt Schaub, QB | ATL | L 27-20 vs. SEA | 39 | 52 | 460 | 1 | 1 | 2 | 1 | 99.8 |
| 2. Drew Brees, QB | NO | W 31-9 vs. ARI | 34 | 43 | 373 | 3 | 1 | 0 | 0 | 116.4 | |
| 3. Jared Goff, QB | LAR | W 24-10 vs. CIN | 17 | 31 | 372 | 2 | 0 | 0 | 0 | 119.3 | |
| 4. Matthew Stafford, QB | DET | W 31-26 vs. NYG | 25 | 32 | 342 | 3 | 1 | 4 | 0 | 129.4 | |
| 5. Andy Dalton, QB | CIN | L 24-10 at LAR | 32 | 52 | 329 | 1 | 0 | 5 | 0 | 86.1 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
James Conner |
1. James Conner, RB | PIT | W 27-14 vs. MIA | 23 | 145 | 6.3 | 1 | 25 | 0 | |
| 2. David Montgomery, RB | CHI | L 17-16 vs. LAC | 27 | 135 | 5.0 | 1 | 55 | 0 | ||
| 3. Nick Chubb, RB | CLE | L 27-13 at NE | 20 | 131 | 6.6 | 0 | 44 | 2 | ||
| 4. Christian McCaffrey, RB | CAR | L 51-13 at SF | 14 | 117 | 8.4 | 1 | 40 | 0 | ||
| 5. Tevin Coleman, RB | SF | W 51-13 vs. CAR | 11 | 105 | 9.5 | 3 | 48 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Cooper Kupp |
1. Cooper Kupp, WR | LAR | W 24-10 vs. CIN | 7 | 220 | 31.4 | 1 | 65 | 0 | |
| 2. Mike Evans, WR | TB | L 27-23 at TEN | 11 | 198 | 18.0 | 2 | 46 | 0 | ||
| 3. Aaron Jones Sr., RB | GB | W 31-24 at KC | 7 | 159 | 22.7 | 2 | 67 | 0 | ||
| 4. Julio Jones, WR | ATL | L 27-20 vs. SEA | 10 | 152 | 15.2 | 0 | 25 | 0 | ||
| 5. Stefon Diggs, WR | MIN | W 19-9 vs. WSH | 7 | 143 | 20.4 | 0 | 39 | 1 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Budda Baker |
1. Budda Baker, S | ARI | L 31-9 at NO | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Jamie Collins Sr., LB | NE | W 27-13 vs. CLE | 12 | 1 | 13 | 1.5 | 0 | 0 | 0 | |
| 3. Matt Milano, LB | BUF | L 31-13 vs. PHI | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Taylor Rapp, S | LAR | W 24-10 vs. CIN | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Lavonte David, LB | TB | L 27-23 at TEN | 6 | 6 | 12 | 0.0 | 0 | 0 | 0 | |