| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Russell Wilson |
1. Russell Wilson, QB | SEA | L 33-27 vs. NO | 32 | 50 | 406 | 2 | 0 | 0 | 0 | 102.6 |
| 2. Jameis Winston, QB | TB | L 32-31 vs. NYG | 23 | 37 | 380 | 3 | 1 | 4 | 0 | 112.4 | |
| 3. Patrick Mahomes, QB | KC | W 33-28 vs. BAL | 27 | 37 | 374 | 3 | 0 | 1 | 0 | 132.0 | |
| 4. Deshaun Watson, QB | HOU | W 27-20 at LAC | 25 | 34 | 351 | 3 | 0 | 2 | 1 | 135.8 | |
| 5. Daniel Jones, QB | NYG | W 32-31 at TB | 23 | 36 | 336 | 2 | 0 | 5 | 2 | 112.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Christian McCaffrey |
1. Christian McCaffrey, RB | CAR | W 38-20 at ARI | 24 | 153 | 6.4 | 1 | 76 | 0 | |
| 2. Ezekiel Elliott, RB | DAL | W 31-6 vs. MIA | 19 | 125 | 6.6 | 0 | 18 | 0 | ||
| 3. Dalvin Cook, RB | MIN | W 34-14 vs. LV | 16 | 110 | 6.9 | 1 | 25 | 0 | ||
| 4. Tony Pollard, RB | DAL | W 31-6 vs. MIA | 13 | 103 | 7.9 | 1 | 28 | 0 | ||
| 5. Mark Ingram II, RB | BAL | L 33-28 at KC | 16 | 103 | 6.4 | 3 | 21 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Mike Evans |
1. Mike Evans, WR | TB | L 32-31 vs. NYG | 8 | 190 | 23.8 | 3 | 55 | 0 | |
| 2. Keenan Allen, WR | LAC | L 27-20 vs. HOU | 13 | 183 | 14.1 | 2 | 34 | 0 | ||
| 3. Tyler Lockett, WR | SEA | L 33-27 vs. NO | 11 | 154 | 14.0 | 1 | 40 | 0 | ||
| 4. Darren Waller, TE | LV | L 34-14 at MIN | 13 | 134 | 10.3 | 0 | 30 | 0 | ||
| 5. Julio Jones, WR | ATL | L 27-24 at IND | 8 | 128 | 16.0 | 1 | 34 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Bobby Wagner |
1. Bobby Wagner, LB | SEA | L 33-27 vs. NO | 6 | 13 | 19 | 0.0 | 0 | 0 | 0 |
| 2. Anthony Walker Jr., LB | IND | W 27-24 vs. ATL | 12 | 3 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Brian Poole, CB | NYJ | L 30-14 at NE | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Marshon Lattimore, CB | NO | W 33-27 at SEA | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Blake Martinez, LB | GB | W 27-16 vs. DEN | 8 | 4 | 12 | 0.0 | 0 | 0 | 0 | |