| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Dak Prescott |
1. Dak Prescott, QB | DAL | L 34-24 vs. GB | 27 | 44 | 463 | 2 | 3 | 3 | 0 | 83.8 |
| 2. Deshaun Watson, QB | HOU | W 53-32 vs. ATL | 28 | 33 | 426 | 5 | 0 | 0 | 0 | 158.3 | |
| 3. Jared Goff, QB | LAR | L 30-29 at SEA | 29 | 49 | 395 | 1 | 1 | 0 | 0 | 83.3 | |
| 4. Gardner Minshew II, QB | JAX | L 34-27 at CAR | 26 | 44 | 374 | 2 | 0 | 2 | 3 | 101.9 | |
| 5. Tom Brady, QB | NE | W 33-7 at WSH | 28 | 42 | 348 | 3 | 1 | 4 | 0 | 106.1 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Christian McCaffrey |
1. Christian McCaffrey, RB | CAR | W 34-27 vs. JAX | 19 | 176 | 9.3 | 2 | 84 | 0 | |
| 2. Dalvin Cook, RB | MIN | W 28-10 at NYG | 21 | 132 | 6.3 | 0 | 41 | 1 | ||
| 3. Marlon Mack, RB | IND | W 19-13 at KC | 29 | 132 | 4.6 | 0 | 30 | 0 | ||
| 4. Josh Jacobs, RB | LV | W 24-21 vs. CHI | 26 | 123 | 4.7 | 2 | 21 | 0 | ||
| 5. Chris Carson, RB | SEA | W 30-29 vs. LAR | 27 | 118 | 4.4 | 0 | 14 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Amari Cooper |
1. Amari Cooper, WR | DAL | L 34-24 vs. GB | 11 | 226 | 20.5 | 1 | 53 | 0 | |
| 2. William Fuller V, WR | HOU | W 53-32 vs. ATL | 14 | 217 | 15.5 | 3 | 44 | 0 | ||
| 3. Michael Thomas, WR | NO | W 31-24 vs. TB | 11 | 182 | 16.5 | 2 | 42 | 0 | ||
| 4. DJ Chark, WR | JAX | L 34-27 at CAR | 8 | 164 | 20.5 | 2 | 37 | 0 | ||
| 5. Gerald Everett, TE | LAR | L 30-29 at SEA | 7 | 136 | 19.4 | 0 | 32 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Shawn Williams |
1. Shawn Williams, S | CIN | L 26-23 vs. ARI | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Troy Reeder, LB | LAR | L 30-29 at SEA | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Nick Vigil, LB | CIN | L 26-23 vs. ARI | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Danny Trevathan, LB | CHI | L 24-21 at LV | 12 | 0 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Damien Wilson, LB | KC | L 19-13 vs. IND | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |