| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jared Goff |
1. Jared Goff, QB | LAR | W 34-7 at ARI | 32 | 43 | 424 | 2 | 0 | 1 | 0 | 120.7 |
| 2. Ryan Fitzpatrick, QB | MIA | W 37-31 vs. PHI | 27 | 39 | 365 | 3 | 1 | 3 | 0 | 113.7 | |
| 3. Dak Prescott, QB | DAL | L 26-15 vs. BUF | 32 | 49 | 355 | 2 | 1 | 4 | 1 | 91.8 | |
| 4. Mitchell Trubisky, QB | CHI | W 24-20 at DET | 29 | 38 | 338 | 3 | 1 | 1 | 0 | 118.1 | |
| 5. Tom Brady, QB | NE | L 28-22 at HOU | 24 | 47 | 326 | 3 | 1 | 3 | 0 | 85.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 31-17 at IND | 26 | 149 | 5.7 | 1 | 34 | 1 | |
| 2. Raheem Mostert, RB | SF | L 20-17 at BAL | 19 | 146 | 7.7 | 1 | 40 | 0 | ||
| 3. Derrius Guice, RB | WSH | W 29-21 at CAR | 10 | 129 | 12.9 | 2 | 60 | 0 | ||
| 4. Josh Jacobs, RB | LV | L 40-9 at KC | 17 | 104 | 6.1 | 0 | 35 | 0 | ||
| 5. Chris Carson, RB | SEA | W 37-30 vs. MIN | 23 | 102 | 4.4 | 1 | 25 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Robert Woods |
1. Robert Woods, WR | LAR | W 34-7 at ARI | 13 | 172 | 13.2 | 0 | 48 | 0 | |
| 2. DeVante Parker, WR | MIA | W 37-31 vs. PHI | 7 | 159 | 22.7 | 2 | 43 | 0 | ||
| 3. Kenny Golladay, WR | DET | L 24-20 vs. CHI | 4 | 158 | 39.5 | 1 | 75 | 0 | ||
| 4. Anthony Miller, WR | CHI | W 24-20 at DET | 9 | 140 | 15.6 | 0 | 35 | 0 | ||
| 5. Alshon Jeffery, WR | PHI | L 37-31 at MIA | 9 | 137 | 15.2 | 1 | 27 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Roquan Smith |
1. Roquan Smith, LB | CHI | W 24-20 at DET | 10 | 6 | 16 | 2.0 | 0 | 0 | 0 |
| 2. Jaylon Smith, LB | DAL | L 26-15 vs. BUF | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Donald Payne, LB | JAX | L 28-11 vs. TB | 6 | 7 | 13 | 1.0 | 0 | 0 | 0 | |
| 4. Sean Lee, LB | DAL | L 26-15 vs. BUF | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Budda Baker, S | ARI | L 34-7 vs. LAR | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |