| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jameis Winston |
1. Jameis Winston, QB | TB | W 38-17 at DET | 28 | 42 | 458 | 4 | 1 | 2 | 0 | 124.9 |
| 2. Patrick Mahomes, QB | KC | W 23-3 vs. DEN | 27 | 34 | 340 | 2 | 1 | 3 | 0 | 115.7 | |
| 3. Mitchell Trubisky, QB | CHI | L 21-13 at GB | 29 | 53 | 334 | 1 | 2 | 3 | 0 | 64.5 | |
| 4. Drew Brees, QB | NO | W 34-7 vs. IND | 29 | 30 | 307 | 4 | 0 | 0 | 0 | 148.9 | |
| 5. Philip Rivers, QB | LAC | L 39-10 vs. MIN | 28 | 39 | 307 | 1 | 3 | 3 | 1 | 71.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Kenyan Drake |
1. Kenyan Drake, RB | ARI | W 38-24 vs. CLE | 22 | 137 | 6.2 | 4 | 21 | 0 | |
| 2. Joe Mixon, RB | CIN | L 34-13 vs. NE | 25 | 136 | 5.4 | 0 | 29 | 0 | ||
| 3. Chris Carson, RB | SEA | W 30-24 at CAR | 24 | 133 | 5.5 | 2 | 23 | 0 | ||
| 4. Tony Pollard, RB | DAL | W 44-21 vs. LAR | 12 | 131 | 10.9 | 1 | 44 | 0 | ||
| 5. Nick Chubb, RB | CLE | L 38-24 at ARI | 17 | 127 | 7.5 | 1 | 33 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Travis Kelce |
1. Travis Kelce, TE | KC | W 23-3 vs. DEN | 11 | 142 | 12.9 | 0 | 21 | 0 | |
| 2. Julio Jones, WR | ATL | W 29-22 at SF | 13 | 134 | 10.3 | 2 | 28 | 0 | ||
| 3. George Kittle, TE | SF | L 29-22 vs. ATL | 13 | 134 | 10.3 | 0 | 21 | 0 | ||
| 4. Terry McLaurin, WR | WSH | L 37-27 vs. PHI | 5 | 130 | 26.0 | 1 | 75 | 0 | ||
| 5. Michael Thomas, WR | NO | W 34-7 vs. IND | 12 | 128 | 10.7 | 1 | 24 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Luke Kuechly |
1. Luke Kuechly, LB | CAR | L 30-24 vs. SEA | 8 | 9 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Zach Cunningham, LB | HOU | W 24-21 at TEN | 10 | 4 | 14 | 0.5 | 0 | 0 | 0 | |
| 3. Donald Payne, LB | JAX | W 20-16 at LV | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Todd Davis, LB | DEN | L 23-3 at KC | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Shaquille Leonard, LB | IND | L 34-7 at NO | 6 | 6 | 12 | 0.0 | 0 | 0 | 0 | |