| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Andy Dalton |
1. Andy Dalton, QB | CIN | L 21-20 at SEA | 35 | 51 | 418 | 2 | 0 | 5 | 2 | 106.5 |
| 2. Dak Prescott, QB | DAL | W 35-17 vs. NYG | 25 | 32 | 405 | 4 | 0 | 0 | 0 | 158.3 | |
| 3. Matthew Stafford, QB | DET | T 27-27 at ARI | 27 | 45 | 385 | 3 | 0 | 3 | 1 | 110.0 | |
| 4. Case Keenum, QB | WSH | L 32-27 at PHI | 30 | 44 | 380 | 3 | 0 | 1 | 0 | 117.6 | |
| 5. Patrick Mahomes, QB | KC | W 40-26 at JAX | 25 | 33 | 378 | 3 | 0 | 0 | 0 | 143.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Marlon Mack |
1. Marlon Mack, RB | IND | L 30-24 at LAC | 25 | 174 | 7.0 | 1 | 63 | 0 | |
| 2. Christian McCaffrey, RB | CAR | L 30-27 vs. LAR | 19 | 128 | 6.7 | 2 | 23 | 0 | ||
| 3. Saquon Barkley, RB | NYG | L 35-17 at DAL | 11 | 120 | 10.9 | 0 | 59 | 0 | ||
| 4. Dalvin Cook, RB | MIN | W 28-12 vs. ATL | 21 | 111 | 5.3 | 2 | 22 | 0 | ||
| 5. Mark Ingram II, RB | BAL | W 59-10 at MIA | 14 | 107 | 7.6 | 2 | 49 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Sammy Watkins |
1. Sammy Watkins, WR | KC | W 40-26 at JAX | 9 | 198 | 22.0 | 3 | 68 | 0 | |
| 2. John Ross, WR | CIN | L 21-20 at SEA | 7 | 158 | 22.6 | 2 | 55 | 0 | ||
| 3. Michael Gallup, WR | DAL | W 35-17 vs. NYG | 7 | 158 | 22.6 | 0 | 62 | 0 | ||
| 4. DeSean Jackson, WR | PHI | W 32-27 vs. WSH | 8 | 154 | 19.3 | 2 | 53 | 0 | ||
| 5. Hollywood Brown, WR | BAL | W 59-10 at MIA | 4 | 147 | 36.8 | 2 | 83 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Cory Littleton |
1. Cory Littleton, LB | LAR | W 30-27 at CAR | 8 | 6 | 14 | 0.0 | 1 | 1 | 0 |
| 2. Thomas Davis Sr., LB | LAC | W 30-24 vs. IND | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Jordan Hicks, LB | ARI | T 27-27 vs. DET | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Josey Jewell, LB | DEN | L 24-16 at LV | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Eric Rowe, S | MIA | L 59-10 vs. BAL | 9 | 2 | 11 | 0.0 | 0 | 0 | 0 | |