| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Derek Carr |
1. Derek Carr, QB | LV | L 16-15 at DEN | 29 | 46 | 391 | 1 | 0 | 2 | 0 | 97.3 |
| 2. Kyler Murray, QB | ARI | L 31-24 at LAR | 26 | 42 | 325 | 2 | 2 | 1 | 2 | 81.9 | |
| 3. Aaron Rodgers, QB | GB | W 23-20 at DET | 27 | 55 | 323 | 2 | 1 | 1 | 0 | 72.0 | |
| 4. Ryan Fitzpatrick, QB | MIA | W 27-24 at NE | 28 | 41 | 320 | 1 | 0 | 2 | 0 | 99.6 | |
| 5. Jared Goff, QB | LAR | W 31-24 vs. ARI | 29 | 45 | 319 | 3 | 0 | 1 | 0 | 107.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 35-14 at HOU | 32 | 211 | 6.6 | 3 | 53 | 0 | |
| 2. Joe Mixon, RB | CIN | W 33-23 vs. CLE | 26 | 162 | 6.2 | 2 | 41 | 0 | ||
| 3. Mike Boone, RB | MIN | L 21-19 vs. CHI | 17 | 148 | 8.7 | 1 | 59 | 0 | ||
| 4. Gus Edwards, RB | BAL | W 28-10 vs. PIT | 21 | 130 | 6.2 | 0 | 38 | 1 | ||
| 5. Damien Williams, RB | KC | W 31-21 vs. LAC | 12 | 124 | 10.3 | 2 | 84 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
DeVante Parker |
1. DeVante Parker, WR | MIA | W 27-24 at NE | 8 | 137 | 17.1 | 0 | 28 | 0 | |
| 2. Breshad Perriman, WR | TB | L 28-22 vs. ATL | 5 | 134 | 26.8 | 1 | 37 | 0 | ||
| 3. A.J. Brown, WR | TEN | W 35-14 at HOU | 4 | 124 | 31.0 | 1 | 51 | 0 | ||
| 4. Duke Williams, WR | BUF | L 13-6 vs. NYJ | 6 | 108 | 18.0 | 0 | 41 | 0 | ||
| 5. Darren Waller, TE | LV | L 16-15 at DEN | 6 | 107 | 17.8 | 0 | 75 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Anthony Walker Jr. |
1. Anthony Walker Jr., LB | IND | L 38-20 at JAX | 12 | 5 | 17 | 0.0 | 0 | 0 | 0 |
| 2. Michael Thomas, S | NYG | L 34-17 vs. PHI | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Dre Greenlaw, LB | SF | W 26-21 at SEA | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Todd Davis, LB | DEN | W 16-15 vs. LV | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Budda Baker, S | ARI | L 31-24 at LAR | 8 | 5 | 13 | 0.5 | 0 | 0 | 0 | |