| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | L 35-32 at TEN | 36 | 50 | 446 | 3 | 0 | 2 | 0 | 119.3 |
| 2. Dak Prescott, QB | DAL | L 28-24 vs. MIN | 28 | 46 | 397 | 3 | 1 | 1 | 0 | 101.4 | |
| 3. Jameis Winston, QB | TB | W 30-27 vs. ARI | 30 | 48 | 358 | 1 | 2 | 4 | 0 | 74.8 | |
| 4. Kyler Murray, QB | ARI | L 30-27 at TB | 27 | 44 | 324 | 3 | 1 | 2 | 0 | 97.2 | |
| 5. Daniel Jones, QB | NYG | L 34-27 at NYJ | 26 | 40 | 308 | 4 | 0 | 6 | 1 | 121.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 35-32 vs. KC | 23 | 188 | 8.2 | 2 | 68 | 0 | |
| 2. Nick Chubb, RB | CLE | W 19-16 vs. BUF | 20 | 116 | 5.8 | 0 | 24 | 0 | ||
| 3. Joe Mixon, RB | CIN | L 49-13 vs. BAL | 30 | 114 | 3.8 | 0 | 15 | 0 | ||
| 4. Christian McCaffrey, RB | CAR | L 24-16 at GB | 20 | 108 | 5.4 | 1 | 18 | 0 | ||
| 5. Melvin Gordon III, RB | LAC | L 26-24 at LV | 22 | 108 | 4.9 | 1 | 24 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tyreek Hill |
1. Tyreek Hill, WR | KC | L 35-32 at TEN | 11 | 157 | 14.3 | 1 | 39 | 0 | |
| 2. Michael Thomas, WR | NO | L 26-9 vs. ATL | 13 | 152 | 11.7 | 0 | 18 | 0 | ||
| 3. Amari Cooper, WR | DAL | L 28-24 vs. MIN | 11 | 147 | 13.4 | 1 | 20 | 0 | ||
| 4. Christian Kirk, WR | ARI | L 30-27 at TB | 6 | 138 | 23.0 | 3 | 69 | 0 | ||
| 5. Darius Slayton, WR | NYG | L 34-27 at NYJ | 10 | 121 | 12.1 | 2 | 39 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Tahir Whitehead |
1. Tahir Whitehead, LB | LV | W 26-24 vs. LAC | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Drue Tranquill, LB | LAC | L 26-24 at LV | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Shaquille Leonard, LB | IND | L 16-12 vs. MIA | 11 | 2 | 13 | 1.0 | 1 | 1 | 0 | |
| 4. Logan Ryan, S | TEN | W 35-32 vs. KC | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Cory Littleton, LB | LAR | L 17-12 at PIT | 8 | 5 | 13 | 0.0 | 1 | 0 | 0 | |