| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Baker Mayfield |
1. Baker Mayfield, QB | CLE | W 41-24 vs. MIA | 24 | 34 | 327 | 3 | 1 | 1 | 0 | 118.1 |
| 2. Sam Darnold, QB | NYJ | W 34-3 vs. LV | 20 | 29 | 315 | 2 | 0 | 1 | 0 | 127.8 | |
| 3. Jameis Winston, QB | TB | W 35-22 at ATL | 18 | 28 | 313 | 3 | 2 | 0 | 0 | 108.2 | |
| 4. Drew Brees, QB | NO | W 34-31 vs. CAR | 30 | 39 | 311 | 3 | 1 | 2 | 0 | 114.4 | |
| 5. Deshaun Watson, QB | HOU | W 20-17 vs. IND | 19 | 30 | 298 | 2 | 1 | 1 | 0 | 104.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 42-20 vs. JAX | 19 | 159 | 8.4 | 2 | 74 | 1 | |
| 2. Rashaad Penny, RB | SEA | W 17-9 at PHI | 14 | 129 | 9.2 | 1 | 58 | 0 | ||
| 3. Mark Ingram II, RB | BAL | W 45-6 at LAR | 15 | 111 | 7.4 | 1 | 25 | 0 | ||
| 4. Nick Chubb, RB | CLE | W 41-24 vs. MIA | 21 | 106 | 5.0 | 1 | 17 | 0 | ||
| 5. Devin Singletary, RB | BUF | W 20-3 vs. DEN | 21 | 106 | 5.0 | 0 | 11 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Chris Godwin Jr. |
1. Chris Godwin Jr., WR | TB | W 35-22 at ATL | 7 | 184 | 26.3 | 2 | 71 | 0 | |
| 2. Jarvis Landry, WR | CLE | W 41-24 vs. MIA | 10 | 148 | 14.8 | 2 | 37 | 0 | ||
| 3. William Fuller V, WR | HOU | W 20-17 vs. IND | 7 | 140 | 20.0 | 0 | 51 | 0 | ||
| 4. A.J. Brown, WR | TEN | W 42-20 vs. JAX | 4 | 135 | 33.8 | 1 | 65 | 0 | ||
| 5. Allen Robinson, WR | CHI | W 19-14 vs. NYG | 6 | 131 | 21.8 | 1 | 49 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Zach Cunningham |
1. Zach Cunningham, LB | HOU | W 20-17 vs. IND | 13 | 3 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Eric Reid, S | CAR | L 34-31 at NO | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Jayon Brown, LB | TEN | W 42-20 vs. JAX | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Alexander Johnson, LB | DEN | L 20-3 at BUF | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 | |
| 5. Mychal Kendricks, LB | SEA | W 17-9 at PHI | 13 | 0 | 13 | 0.0 | 0 | 0 | 0 | |