| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matthew Stafford |
1. Matthew Stafford, QB | DET | L 31-24 at LV | 26 | 41 | 406 | 3 | 1 | 2 | 1 | 110.4 |
| 2. Russell Wilson, QB | SEA | W 40-34 vs. TB | 29 | 43 | 378 | 5 | 0 | 3 | 0 | 133.7 | |
| 3. Jameis Winston, QB | TB | L 40-34 at SEA | 29 | 44 | 335 | 2 | 0 | 2 | 1 | 103.9 | |
| 4. Ryan Tannehill, QB | TEN | L 30-20 at CAR | 27 | 39 | 331 | 1 | 2 | 4 | 0 | 82.3 | |
| 5. Jimmy Garoppolo, QB | SF | W 28-25 at ARI | 28 | 37 | 317 | 4 | 0 | 1 | 0 | 136.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Carlos Hyde |
1. Carlos Hyde, RB | HOU | W 26-3 at JAX | 19 | 160 | 8.4 | 0 | 58 | 1 | |
| 2. Christian McCaffrey, RB | CAR | W 30-20 vs. TEN | 24 | 146 | 6.1 | 2 | 58 | 0 | ||
| 3. Ezekiel Elliott, RB | DAL | W 37-18 at NYG | 23 | 139 | 6.0 | 0 | 19 | 0 | ||
| 4. Damien Williams, RB | KC | W 26-23 vs. MIN | 12 | 125 | 10.4 | 1 | 91 | 0 | ||
| 5. Josh Jacobs, RB | LV | W 31-24 vs. DET | 28 | 120 | 4.3 | 2 | 17 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Mike Evans |
1. Mike Evans, WR | TB | L 40-34 at SEA | 12 | 180 | 15.0 | 1 | 25 | 0 | |
| 2. Tyler Lockett, WR | SEA | W 40-34 vs. TB | 13 | 152 | 11.7 | 2 | 30 | 0 | ||
| 3. Tyreek Hill, WR | KC | W 26-23 vs. MIN | 6 | 140 | 23.3 | 1 | 41 | 0 | ||
| 4. Kenny Golladay, WR | DET | L 31-24 at LV | 4 | 132 | 33.0 | 1 | 59 | 0 | ||
| 5. Marvin Jones Jr., WR | DET | L 31-24 at LV | 8 | 126 | 15.8 | 1 | 47 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Budda Baker |
1. Budda Baker, S | ARI | L 28-25 vs. SF | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Dont'a Hightower, LB | NE | L 37-20 at BAL | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Alexander Johnson, LB | DEN | W 24-19 vs. CLE | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Sean Lee, LB | DAL | W 37-18 at NYG | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Jabrill Peppers, S | NYG | L 37-18 vs. DAL | 7 | 5 | 12 | 0.0 | 1 | 0 | 0 | |