| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | W 28-10 at LV | 30 | 44 | 443 | 4 | 0 | 2 | 1 | 131.2 |
| 2. Kyler Murray, QB | ARI | L 23-17 at BAL | 25 | 40 | 349 | 0 | 0 | 3 | 0 | 90.5 | |
| 3. Cam Newton, QB | CAR | L 20-14 vs. TB | 25 | 51 | 333 | 0 | 0 | 3 | 1 | 70.1 | |
| 4. Baker Mayfield, QB | CLE | W 23-3 at NYJ | 19 | 35 | 325 | 1 | 1 | 3 | 0 | 83.6 | |
| 5. Matt Ryan, QB | ATL | W 24-20 vs. PHI | 27 | 43 | 320 | 3 | 3 | 1 | 0 | 79.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Dalvin Cook |
1. Dalvin Cook, RB | MIN | L 21-16 at GB | 20 | 154 | 7.7 | 1 | 75 | 0 | |
| 2. Matt Breida, RB | SF | W 41-17 at CIN | 12 | 121 | 10.1 | 0 | 34 | 0 | ||
| 3. Lamar Jackson, QB | BAL | W 23-17 vs. ARI | 16 | 120 | 7.5 | 0 | 19 | 0 | ||
| 4. Aaron Jones Sr., RB | GB | W 21-16 vs. MIN | 23 | 116 | 5.0 | 1 | 15 | 0 | ||
| 5. Ezekiel Elliott, RB | DAL | W 31-21 at WSH | 23 | 111 | 4.8 | 1 | 27 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Demarcus Robinson |
1. Demarcus Robinson, WR | KC | W 28-10 at LV | 6 | 172 | 28.7 | 2 | 44 | 0 | |
| 2. Odell Beckham Jr., WR | CLE | W 23-3 at NYJ | 6 | 161 | 26.8 | 1 | 89 | 0 | ||
| 3. Tyler Boyd, WR | CIN | L 41-17 vs. SF | 10 | 122 | 12.2 | 0 | 47 | 0 | ||
| 4. Chris Godwin Jr., WR | TB | W 20-14 at CAR | 8 | 121 | 15.1 | 1 | 24 | 0 | ||
| 5. Cooper Kupp, WR | LAR | W 27-9 vs. NO | 5 | 120 | 24.0 | 0 | 66 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Luke Kuechly |
1. Luke Kuechly, LB | CAR | L 20-14 vs. TB | 8 | 10 | 18 | 0.0 | 0 | 0 | 0 |
| 2. Preston Brown, LB | CIN | L 41-17 vs. SF | 4 | 10 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Joe Schobert, LB | CLE | W 23-3 at NYJ | 10 | 3 | 13 | 0.0 | 1 | 0 | 0 | |
| 4. Blake Martinez, LB | GB | W 21-16 vs. MIN | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Roquan Smith, LB | CHI | W 16-14 at DEN | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |