| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Dak Prescott |
1. Dak Prescott, QB | DAL | W 35-27 at DET | 29 | 46 | 444 | 3 | 0 | 1 | 0 | 116.6 |
| 2. Jimmy Garoppolo, QB | SF | W 36-26 vs. ARI | 34 | 45 | 424 | 4 | 2 | 2 | 0 | 115.4 | |
| 3. Philip Rivers, QB | LAC | L 24-17 vs. KC | 28 | 52 | 353 | 1 | 4 | 2 | 0 | 49.6 | |
| 4. Kyle Allen, QB | CAR | L 29-3 vs. ATL | 31 | 50 | 325 | 0 | 4 | 5 | 0 | 47.5 | |
| 5. Ryan Fitzpatrick, QB | MIA | L 37-20 vs. BUF | 32 | 45 | 323 | 0 | 0 | 7 | 0 | 91.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jonathan Williams |
1. Jonathan Williams, RB | IND | W 33-13 vs. JAX | 13 | 116 | 8.9 | 0 | 48 | 0 | |
| 2. Gus Edwards, RB | BAL | W 41-7 vs. HOU | 8 | 112 | 14.0 | 1 | 63 | 0 | ||
| 3. Josh Jacobs, RB | LV | W 17-10 vs. CIN | 23 | 112 | 4.9 | 0 | 21 | 1 | ||
| 4. Marlon Mack, RB | IND | W 33-13 vs. JAX | 14 | 109 | 7.8 | 1 | 20 | 0 | ||
| 5. Todd Gurley, RB | LAR | W 17-7 vs. CHI | 25 | 97 | 3.9 | 1 | 13 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Michael Gallup |
1. Michael Gallup, WR | DAL | W 35-27 at DET | 9 | 148 | 16.4 | 0 | 41 | 0 | |
| 2. Calvin Ridley, WR | ATL | W 29-3 at CAR | 8 | 143 | 17.9 | 1 | 36 | 0 | ||
| 3. John Brown, WR | BUF | W 37-20 at MIA | 9 | 137 | 15.2 | 2 | 40 | 0 | ||
| 4. DeVante Parker, WR | MIA | L 37-20 vs. BUF | 7 | 135 | 19.3 | 0 | 50 | 0 | ||
| 5. Deebo Samuel Sr., WR | SF | W 36-26 vs. ARI | 8 | 134 | 16.8 | 0 | 26 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Budda Baker |
1. Budda Baker, S | ARI | L 36-26 at SF | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Devin White, LB | TB | L 34-17 vs. NO | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Fred Warner, LB | SF | W 36-26 vs. ARI | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Jordan Hicks, LB | ARI | L 36-26 at SF | 8 | 4 | 12 | 1.0 | 0 | 1 | 0 | |
| 5. Thomas Davis Sr., LB | LAC | L 24-17 vs. KC | 6 | 6 | 12 | 0.0 | 0 | 0 | 0 | |