| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jameis Winston |
1. Jameis Winston, QB | TB | L 37-26 vs. CAR | 30 | 54 | 400 | 1 | 5 | 7 | 1 | 46.8 |
| 2. Matt Ryan, QB | ATL | L 34-33 at ARI | 30 | 36 | 356 | 4 | 0 | 2 | 0 | 144.9 | |
| 3. Kyler Murray, QB | ARI | W 34-33 vs. ATL | 27 | 37 | 340 | 3 | 0 | 0 | 0 | 128.2 | |
| 4. Sam Darnold, QB | NYJ | W 24-22 vs. DAL | 23 | 32 | 338 | 2 | 1 | 2 | 0 | 113.8 | |
| 5. Tom Brady, QB | NE | W 35-14 vs. NYG | 31 | 41 | 334 | 0 | 1 | 3 | 1 | 88.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Lamar Jackson |
1. Lamar Jackson, QB | BAL | W 23-17 vs. CIN | 19 | 152 | 8.0 | 1 | 36 | 0 | |
| 2. Chris Carson, RB | SEA | W 32-28 at CLE | 24 | 124 | 5.2 | 1 | 25 | 0 | ||
| 3. Nick Chubb, RB | CLE | L 32-28 vs. SEA | 20 | 122 | 6.1 | 2 | 52 | 1 | ||
| 4. Adrian Peterson, RB | WSH | W 17-16 at MIA | 23 | 118 | 5.1 | 0 | 25 | 0 | ||
| 5. Carlos Hyde, RB | HOU | W 31-24 at KC | 26 | 116 | 4.5 | 1 | 26 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Stefon Diggs |
1. Stefon Diggs, WR | MIN | W 38-20 vs. PHI | 7 | 167 | 23.9 | 3 | 62 | 0 | |
| 2. Chris Godwin Jr., WR | TB | L 37-26 vs. CAR | 10 | 151 | 15.1 | 0 | 26 | 0 | ||
| 3. Robbie Chosen, WR | NYJ | W 24-22 vs. DAL | 5 | 125 | 25.0 | 1 | 92 | 0 | ||
| 4. Kenny Golladay, WR | DET | L 23-22 at GB | 5 | 121 | 24.2 | 0 | 66 | 0 | ||
| 5. Austin Hooper, TE | ATL | L 34-33 at ARI | 8 | 117 | 14.6 | 1 | 30 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Cory Littleton |
1. Cory Littleton, LB | LAR | L 20-7 vs. SF | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Nick Vigil, LB | CIN | L 23-17 at BAL | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. David Mayo, LB | NYG | L 35-14 at NE | 9 | 4 | 13 | 0.5 | 0 | 0 | 0 | |
| 4. Landon Collins, S | WSH | W 17-16 at MIA | 10 | 2 | 12 | 1.0 | 1 | 0 | 0 | |
| 5. Alec Ogletree, LB | NYG | L 35-14 at NE | 9 | 3 | 12 | 1.0 | 0 | 0 | 0 | |