| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matthew Stafford |
1. Matthew Stafford, QB | LAR | W 20-17 vs. SF | 31 | 45 | 337 | 2 | 1 | 2 | 0 | 96.3 |
| 2. Patrick Mahomes, QB | KC | L 27-24 vs. CIN | 26 | 39 | 275 | 3 | 2 | 4 | 0 | 91.3 | |
| 3. Joe Burrow, QB | CIN | W 27-24 at KC | 23 | 38 | 250 | 2 | 1 | 1 | 0 | 86.5 | |
| 4. Jimmy Garoppolo, QB | SF | L 20-17 at LAR | 16 | 30 | 232 | 2 | 1 | 0 | 0 | 87.1 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Joe Mixon |
1. Joe Mixon, RB | CIN | W 27-24 at KC | 21 | 88 | 4.2 | 0 | 23 | 0 | |
| 2. Jerick McKinnon, RB | KC | L 27-24 vs. CIN | 12 | 65 | 5.4 | 0 | 14 | 0 | ||
| 3. Cam Akers, RB | LAR | W 20-17 vs. SF | 13 | 48 | 3.7 | 0 | 14 | 0 | ||
| 4. Clyde Edwards-Helaire, RB | KC | L 27-24 vs. CIN | 6 | 36 | 6.0 | 0 | 14 | 0 | ||
| 5. Deebo Samuel, WR | SF | L 20-17 at LAR | 7 | 26 | 3.7 | 0 | 9 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Cooper Kupp |
1. Cooper Kupp, WR | LAR | W 20-17 vs. SF | 11 | 142 | 12.9 | 2 | 25 | 0 | |
| 2. Odell Beckham Jr., WR | LAR | W 20-17 vs. SF | 9 | 113 | 12.6 | 0 | 29 | 0 | ||
| 3. Tee Higgins, WR | CIN | W 27-24 at KC | 6 | 103 | 17.2 | 0 | 44 | 0 | ||
| 4. Travis Kelce, TE | KC | L 27-24 vs. CIN | 10 | 95 | 9.5 | 1 | 19 | 0 | ||
| 5. Tyreek Hill, WR | KC | L 27-24 vs. CIN | 7 | 78 | 11.1 | 1 | 33 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Ambry Thomas |
1. Ambry Thomas, CB | SF | L 20-17 at LAR | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 |
| 2. L'Jarius Sneed, CB | KC | L 27-24 vs. CIN | 8 | 2 | 10 | 0.0 | 0 | 1 | 0 | |
| 3. Fred Warner, LB | SF | L 20-17 at LAR | 7 | 3 | 10 | 0.0 | 0 | 0 | 0 | |
| 4. Logan Wilson, LB | CIN | W 27-24 at KC | 3 | 7 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Eric Weddle, S | LAR | W 20-17 vs. SF | 4 | 5 | 9 | 0.0 | 0 | 0 | 0 | |