| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Tom Brady |
1. Tom Brady, QB | TB | L 34-24 at LAR | 41 | 55 | 432 | 1 | 0 | 3 | 0 | 103.0 |
| 2. Derek Carr, QB | LV | W 31-28 vs. MIA | 26 | 43 | 386 | 2 | 1 | 3 | 0 | 95.7 | |
| 3. Josh Allen, QB | BUF | W 43-21 vs. WSH | 32 | 43 | 358 | 4 | 0 | 0 | 0 | 129.8 | |
| 4. Matthew Stafford, QB | LAR | W 34-24 vs. TB | 27 | 38 | 343 | 4 | 0 | 1 | 0 | 134.0 | |
| 5. Jalen Hurts, QB | PHI | L 41-21 at DAL | 25 | 39 | 326 | 2 | 2 | 2 | 0 | 86.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 25-16 vs. IND | 28 | 113 | 4.0 | 0 | 19 | 0 | |
| 2. Alexander Mattison, RB | MIN | W 30-17 vs. SEA | 26 | 112 | 4.3 | 0 | 24 | 0 | ||
| 3. Peyton Barber, RB | LV | W 31-28 vs. MIA | 23 | 111 | 4.8 | 1 | 27 | 0 | ||
| 4. Clyde Edwards-Helaire, RB | KC | L 30-24 vs. LAC | 17 | 100 | 5.9 | 0 | 14 | 1 | ||
| 5. Ezekiel Elliott, RB | DAL | W 41-21 vs. PHI | 17 | 95 | 5.6 | 2 | 13 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Davante Adams |
1. Davante Adams, WR | GB | W 30-28 at SF | 12 | 132 | 11.0 | 1 | 25 | 0 | |
| 2. DJ Moore, WR | CAR | W 24-9 at HOU | 8 | 126 | 15.8 | 0 | 29 | 0 | ||
| 3. Mike Williams, WR | LAC | W 30-24 at KC | 7 | 122 | 17.4 | 2 | 43 | 0 | ||
| 4. DeSean Jackson, WR | LAR | W 34-24 vs. TB | 3 | 120 | 40.0 | 1 | 75 | 0 | ||
| 5. Justin Jefferson, WR | MIN | W 30-17 vs. SEA | 9 | 118 | 13.1 | 1 | 28 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Cole Holcomb |
1. Cole Holcomb, LB | WSH | L 43-21 at BUF | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Denzel Perryman, LB | LV | W 31-28 vs. MIA | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Foyesade Oluokun, LB | ATL | W 17-14 at NYG | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Anthony Harris, S | PHI | L 41-21 at DAL | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Zach Cunningham, LB | HOU | L 24-9 vs. CAR | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |