| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Dak Prescott |
1. Dak Prescott, QB | DAL | L 36-33 vs. LV | 32 | 47 | 375 | 2 | 0 | 1 | 0 | 106.3 |
| 2. Derek Carr, QB | LV | W 36-33 at DAL | 24 | 39 | 373 | 1 | 0 | 3 | 0 | 101.8 | |
| 3. Andy Dalton, QB | CHI | W 16-14 at DET | 24 | 39 | 317 | 1 | 1 | 1 | 0 | 85.1 | |
| 4. Mac Jones, QB | NE | W 36-13 vs. TEN | 23 | 32 | 310 | 2 | 0 | 2 | 0 | 123.2 | |
| 5. Aaron Rodgers, QB | GB | W 36-28 vs. LAR | 28 | 45 | 307 | 2 | 0 | 1 | 0 | 97.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Joe Mixon |
1. Joe Mixon, RB | CIN | W 41-10 vs. PIT | 28 | 165 | 5.9 | 2 | 32 | 0 | |
| 2. Elijah Mitchell, RB | SF | W 34-26 vs. MIN | 27 | 133 | 4.9 | 1 | 15 | 0 | ||
| 3. Dontrell Hilliard, RB | TEN | L 36-13 at NE | 12 | 131 | 10.9 | 1 | 68 | 1 | ||
| 4. Antonio Gibson, RB | WSH | W 17-15 vs. SEA | 29 | 111 | 3.8 | 0 | 17 | 0 | ||
| 5. D'Onta Foreman, RB | TEN | L 36-13 at NE | 19 | 109 | 5.7 | 0 | 30 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Jaylen Waddle |
1. Jaylen Waddle, WR | MIA | W 33-10 vs. CAR | 9 | 137 | 15.2 | 1 | 57 | 0 | |
| 2. Hunter Renfrow, WR | LV | W 36-33 at DAL | 8 | 134 | 16.8 | 0 | 54 | 0 | ||
| 3. Rob Gronkowski, TE | TB | W 38-31 at IND | 7 | 123 | 17.6 | 0 | 32 | 0 | ||
| 4. Darnell Mooney, WR | CHI | W 16-14 at DET | 5 | 123 | 24.6 | 0 | 52 | 0 | ||
| 5. Tee Higgins, WR | CIN | W 41-10 vs. PIT | 6 | 114 | 19.0 | 1 | 32 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Shaquille Leonard |
1. Shaquille Leonard, LB | IND | L 38-31 vs. TB | 12 | 3 | 15 | 0.0 | 1 | 0 | 0 |
| 2. Ronnie Harrison Jr., LB | CLE | L 16-10 at BAL | 12 | 2 | 14 | 0.0 | 0 | 1 | 0 | |
| 3. Bobby Wagner, LB | SEA | L 17-15 at WSH | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Jordyn Brooks, LB | SEA | L 17-15 at WSH | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Shaq Thompson, LB | CAR | L 33-10 at MIA | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |