| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Daniel Jones |
1. Daniel Jones, QB | NYG | W 27-21 at NO | 28 | 40 | 402 | 2 | 1 | 0 | 0 | 108.5 |
| 2. Jalen Hurts, QB | PHI | L 42-30 vs. KC | 32 | 48 | 387 | 2 | 0 | 3 | 0 | 105.1 | |
| 3. Joe Burrow, QB | CIN | W 24-21 vs. JAX | 25 | 32 | 348 | 2 | 0 | 1 | 0 | 132.8 | |
| 4. Lamar Jackson, QB | BAL | W 23-7 at DEN | 22 | 37 | 316 | 1 | 0 | 3 | 0 | 96.2 | |
| 5. Sam Darnold, QB | CAR | L 36-28 at DAL | 26 | 39 | 301 | 2 | 2 | 5 | 0 | 85.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | L 27-24 at NYJ | 33 | 157 | 4.8 | 1 | 22 | 0 | |
| 2. Ezekiel Elliott, RB | DAL | W 36-28 vs. CAR | 20 | 143 | 7.2 | 1 | 47 | 0 | ||
| 3. Chase Edmonds, RB | ARI | W 37-20 at LAR | 12 | 120 | 10.0 | 0 | 54 | 0 | ||
| 4. Alvin Kamara, RB | NO | L 27-21 vs. NYG | 26 | 120 | 4.6 | 0 | 10 | 0 | ||
| 5. Austin Ekeler, RB | LAC | W 28-14 vs. LV | 15 | 117 | 7.8 | 1 | 20 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tyreek Hill |
1. Tyreek Hill, WR | KC | W 42-30 at PHI | 11 | 186 | 16.9 | 3 | 44 | 0 | |
| 2. Deebo Samuel Sr., WR | SF | L 28-21 vs. SEA | 8 | 156 | 19.5 | 2 | 76 | 0 | ||
| 3. Darnell Mooney, WR | CHI | W 24-14 vs. DET | 5 | 125 | 25.0 | 0 | 64 | 0 | ||
| 4. Terry McLaurin, WR | WSH | W 34-30 at ATL | 6 | 123 | 20.5 | 2 | 33 | 0 | ||
| 5. DeVonta Smith, WR | PHI | L 42-30 vs. KC | 7 | 122 | 17.4 | 0 | 37 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Cory Littleton |
1. Cory Littleton, LB | LV | L 28-14 at LAC | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 |
| 2. C.J. Mosley, LB | NYJ | W 27-24 vs. TEN | 10 | 3 | 13 | 1.0 | 0 | 0 | 0 | |
| 3. Alec Ogletree, LB | CHI | W 24-14 vs. DET | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Quincy Williams, LB | NYJ | W 27-24 vs. TEN | 10 | 2 | 12 | 1.0 | 0 | 0 | 0 | |
| 5. Malcolm Jenkins, S | NO | L 27-21 vs. NYG | 8 | 4 | 12 | 0.0 | 0 | 0 | 0 | |