| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Justin Herbert |
1. Justin Herbert, QB | LAC | W 27-24 at PHI | 32 | 38 | 356 | 2 | 0 | 0 | 0 | 123.2 |
| 2. Matt Ryan, QB | ATL | W 27-25 at NO | 23 | 30 | 343 | 2 | 0 | 2 | 0 | 135.8 | |
| 3. Jimmy Garoppolo, QB | SF | L 31-17 vs. ARI | 28 | 40 | 326 | 2 | 1 | 5 | 0 | 100.6 | |
| 4. Josh Johnson, QB | NYJ | L 45-30 at IND | 27 | 41 | 317 | 3 | 1 | 2 | 0 | 103.4 | |
| 5. Derek Carr, QB | LV | L 23-16 at NYG | 30 | 46 | 296 | 1 | 2 | 1 | 1 | 72.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jonathan Taylor |
1. Jonathan Taylor, RB | IND | W 45-30 vs. NYJ | 19 | 172 | 9.1 | 2 | 78 | 0 | |
| 2. Nick Chubb, RB | CLE | W 41-16 at CIN | 14 | 137 | 9.8 | 2 | 70 | 0 | ||
| 3. Lamar Jackson, QB | BAL | W 34-31 vs. MIN | 21 | 120 | 5.7 | 0 | 12 | 0 | ||
| 4. Javonte Williams, RB | DEN | W 30-16 at DAL | 17 | 111 | 6.5 | 0 | 30 | 0 | ||
| 5. Dalvin Cook, RB | MIN | L 34-31 at BAL | 17 | 110 | 6.5 | 0 | 66 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Cordarrelle Patterson |
1. Cordarrelle Patterson, RB | ATL | W 27-25 at NO | 6 | 126 | 21.0 | 0 | 64 | 0 | |
| 2. Hollywood Brown, WR | BAL | W 34-31 vs. MIN | 9 | 116 | 12.9 | 0 | 22 | 0 | ||
| 3. DeVonta Smith, WR | PHI | L 27-24 vs. LAC | 5 | 116 | 23.2 | 1 | 28 | 0 | ||
| 4. Keenan Allen, WR | LAC | W 27-24 at PHI | 12 | 104 | 8.7 | 0 | 18 | 0 | ||
| 5. George Kittle, TE | SF | L 31-17 vs. ARI | 6 | 101 | 16.8 | 1 | 29 | 1 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Eric Kendricks |
1. Eric Kendricks, LB | MIN | L 34-31 at BAL | 9 | 9 | 18 | 0.0 | 0 | 0 | 0 |
| 2. Anthony Walker Jr., LB | CLE | W 41-16 at CIN | 12 | 2 | 14 | 1.0 | 0 | 0 | 0 | |
| 3. T.J. Edwards, LB | PHI | L 27-24 vs. LAC | 5 | 9 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Fred Warner, LB | SF | L 31-17 vs. ARI | 5 | 8 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Cam Bynum, S | MIN | L 34-31 at BAL | 8 | 4 | 12 | 0.0 | 0 | 1 | 0 | |