| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Joe Burrow |
1. Joe Burrow, QB | CIN | W 41-17 at BAL | 23 | 38 | 416 | 3 | 1 | 1 | 0 | 113.5 |
| 2. Matt Ryan, QB | ATL | W 30-28 at MIA | 25 | 40 | 336 | 2 | 1 | 1 | 1 | 95.4 | |
| 3. Matthew Stafford, QB | LAR | W 28-19 vs. DET | 28 | 41 | 334 | 3 | 0 | 1 | 0 | 117.3 | |
| 4. Derek Carr, QB | LV | W 33-22 vs. PHI | 31 | 34 | 323 | 2 | 1 | 0 | 0 | 113.6 | |
| 5. Mac Jones, QB | NE | W 54-13 vs. NYJ | 24 | 36 | 307 | 2 | 0 | 1 | 0 | 111.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
D'Ernest Johnson |
1. D'Ernest Johnson, RB | CLE | W 17-14 vs. DEN | 22 | 146 | 6.6 | 1 | 20 | 0 | |
| 2. Elijah Mitchell, RB | SF | L 30-18 vs. IND | 18 | 107 | 5.9 | 1 | 20 | 0 | ||
| 3. Jonathan Taylor, RB | IND | W 30-18 at SF | 18 | 107 | 5.9 | 1 | 33 | 1 | ||
| 4. Damien Harris, RB | NE | W 54-13 vs. NYJ | 14 | 106 | 7.6 | 2 | 32 | 0 | ||
| 5. Khalil Herbert, RB | CHI | L 38-3 at TB | 18 | 100 | 5.6 | 0 | 29 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Ja'Marr Chase |
1. Ja'Marr Chase, WR | CIN | W 41-17 at BAL | 8 | 201 | 25.1 | 1 | 82 | 0 | |
| 2. Kyle Pitts Sr., TE | ATL | W 30-28 at MIA | 7 | 163 | 23.3 | 0 | 39 | 0 | ||
| 3. Cooper Kupp, WR | LAR | W 28-19 vs. DET | 10 | 156 | 15.6 | 2 | 59 | 0 | ||
| 4. A.J. Brown, WR | TEN | W 27-3 vs. KC | 8 | 133 | 16.6 | 1 | 46 | 0 | ||
| 5. Alvin Kamara, RB | NO | W 13-10 at SEA | 10 | 128 | 12.8 | 1 | 31 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Deion Jones |
1. Deion Jones, LB | ATL | W 30-28 at MIA | 11 | 4 | 15 | 1.0 | 0 | 0 | 0 |
| 2. Nick Bolton, LB | KC | L 27-3 at TEN | 9 | 6 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. De'Vondre Campbell, LB | GB | W 24-10 vs. WSH | 11 | 3 | 14 | 0.0 | 2 | 0 | 0 | |
| 4. Foyesade Oluokun, LB | ATL | W 30-28 at MIA | 8 | 5 | 13 | 0.0 | 0 | 1 | 0 | |
| 5. Roquan Smith, LB | CHI | L 38-3 at TB | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |