| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | W 41-14 at LV | 35 | 50 | 406 | 5 | 0 | 0 | 0 | 127.6 |
| 2. Josh Allen, QB | BUF | W 45-17 at NYJ | 21 | 28 | 366 | 2 | 1 | 2 | 0 | 125.6 | |
| 3. Trevor Siemian, QB | NO | L 23-21 at TEN | 19 | 34 | 298 | 2 | 0 | 4 | 0 | 104.8 | |
| 4. Dak Prescott, QB | DAL | W 43-3 vs. ATL | 24 | 31 | 296 | 2 | 0 | 0 | 0 | 127.9 | |
| 5. Kirk Cousins, QB | MIN | W 27-20 at LAC | 25 | 37 | 294 | 2 | 0 | 2 | 1 | 109.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
D'Andre Swift |
1. D'Andre Swift, RB | DET | T 16-16 at PIT | 33 | 130 | 3.9 | 0 | 21 | 0 | |
| 2. Jonathan Taylor, RB | IND | W 23-17 vs. JAX | 21 | 116 | 5.5 | 1 | 34 | 0 | ||
| 3. Najee Harris, RB | PIT | T 16-16 vs. DET | 26 | 105 | 4.0 | 0 | 12 | 0 | ||
| 4. Rhamondre Stevenson, RB | NE | W 45-7 vs. CLE | 20 | 100 | 5.0 | 2 | 18 | 0 | ||
| 5. D'Ernest Johnson, RB | CLE | L 45-7 at NE | 19 | 99 | 5.2 | 0 | 24 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Stefon Diggs |
1. Stefon Diggs, WR | BUF | W 45-17 at NYJ | 8 | 162 | 20.3 | 1 | 57 | 0 | |
| 2. Justin Jefferson, WR | MIN | W 27-20 at LAC | 9 | 143 | 15.9 | 0 | 27 | 0 | ||
| 3. Cooper Kupp, WR | LAR | L 31-10 at SF | 11 | 122 | 11.1 | 0 | 29 | 0 | ||
| 4. Travis Kelce, TE | KC | W 41-14 at LV | 8 | 119 | 14.9 | 0 | 30 | 0 | ||
| 5. Gabe Davis, WR | BUF | W 45-17 at NYJ | 3 | 105 | 35.0 | 0 | 49 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Devin White |
1. Devin White, LB | TB | L 29-19 at WSH | 13 | 5 | 18 | 2.0 | 0 | 0 | 0 |
| 2. Foyesade Oluokun, LB | ATL | L 43-3 at DAL | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Lavonte David, LB | TB | L 29-19 at WSH | 5 | 9 | 14 | 0.0 | 1 | 0 | 0 | |
| 4. Jordyn Brooks, LB | SEA | L 17-0 at GB | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Joe Schobert, LB | PIT | T 16-16 vs. DET | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |