| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Dak Prescott |
1. Dak Prescott, QB | DAL | W 35-29 at NE | 36 | 51 | 445 | 3 | 1 | 0 | 1 | 108.7 |
| 2. Patrick Mahomes, QB | KC | W 31-13 at WSH | 32 | 47 | 397 | 2 | 2 | 3 | 0 | 90.5 | |
| 3. Kirk Cousins, QB | MIN | W 34-28 at CAR | 33 | 48 | 373 | 3 | 0 | 0 | 0 | 112.6 | |
| 4. Josh Allen, QB | BUF | L 34-31 at TEN | 35 | 47 | 353 | 3 | 1 | 3 | 0 | 107.8 | |
| 5. Derek Carr, QB | LV | W 34-24 at DEN | 18 | 27 | 341 | 2 | 0 | 2 | 0 | 134.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jonathan Taylor |
1. Jonathan Taylor, RB | IND | W 31-3 vs. HOU | 14 | 145 | 10.4 | 2 | 83 | 0 | |
| 2. Derrick Henry, RB | TEN | W 34-31 vs. BUF | 20 | 143 | 7.2 | 3 | 76 | 0 | ||
| 3. Dalvin Cook, RB | MIN | W 34-28 at CAR | 29 | 140 | 4.8 | 1 | 23 | 0 | ||
| 4. Damien Harris, RB | NE | L 35-29 vs. DAL | 18 | 101 | 5.6 | 1 | 21 | 0 | ||
| 5. Alex Collins, RB | SEA | L 23-20 at PIT | 20 | 101 | 5.1 | 1 | 21 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
CeeDee Lamb |
1. CeeDee Lamb, WR | DAL | W 35-29 at NE | 9 | 149 | 16.6 | 2 | 35 | 0 | |
| 2. Cooper Kupp, WR | LAR | W 38-11 at NYG | 9 | 130 | 14.4 | 2 | 30 | 0 | ||
| 3. Adam Thielen, WR | MIN | W 34-28 at CAR | 11 | 126 | 11.5 | 1 | 35 | 0 | ||
| 4. Mike Gesicki, TE | MIA | L 23-20 at JAX | 8 | 115 | 14.4 | 0 | 32 | 0 | ||
| 5. Donovan Peoples-Jones, WR | CLE | L 37-14 vs. ARI | 4 | 101 | 25.3 | 2 | 57 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Alex Singleton |
1. Alex Singleton, LB | PHI | L 28-22 vs. TB | 8 | 7 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Bobby Okereke, LB | IND | W 31-3 vs. HOU | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. David Long Jr., LB | TEN | W 34-31 vs. BUF | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Bobby Wagner, LB | SEA | L 23-20 at PIT | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Jordyn Brooks, LB | SEA | L 23-20 at PIT | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |