| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Kyler Murray |
1. Kyler Murray, QB | ARI | W 34-33 vs. MIN | 29 | 36 | 400 | 3 | 2 | 3 | 0 | 117.6 |
| 2. Derek Carr, QB | LV | W 26-17 at PIT | 28 | 37 | 382 | 2 | 0 | 2 | 0 | 126.2 | |
| 3. Ryan Tannehill, QB | TEN | W 33-30 at SEA | 27 | 40 | 347 | 0 | 0 | 3 | 1 | 94.5 | |
| 4. Russell Wilson, QB | SEA | L 33-30 vs. TEN | 22 | 31 | 343 | 2 | 0 | 3 | 0 | 128.8 | |
| 5. Patrick Mahomes, QB | KC | L 36-35 at BAL | 24 | 31 | 343 | 3 | 1 | 0 | 0 | 131.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | TEN | W 33-30 at SEA | 35 | 182 | 5.2 | 3 | 60 | 0 | |
| 2. Dalvin Cook, RB | MIN | L 34-33 at ARI | 22 | 131 | 6.0 | 0 | 16 | 0 | ||
| 3. Tony Pollard, RB | DAL | W 20-17 at LAC | 13 | 109 | 8.4 | 1 | 28 | 0 | ||
| 4. Lamar Jackson, QB | BAL | W 36-35 vs. KC | 16 | 107 | 6.7 | 2 | 21 | 0 | ||
| 5. Daniel Jones, QB | NYG | L 30-29 at WSH | 9 | 95 | 10.6 | 1 | 46 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tyler Lockett |
1. Tyler Lockett, WR | SEA | L 33-30 vs. TEN | 8 | 178 | 22.3 | 1 | 63 | 0 | |
| 2. Cooper Kupp, WR | LAR | W 27-24 at IND | 9 | 163 | 18.1 | 2 | 44 | 0 | ||
| 3. Courtland Sutton, WR | DEN | W 23-13 at JAX | 9 | 159 | 17.7 | 0 | 55 | 0 | ||
| 4. Julio Jones, WR | TEN | W 33-30 at SEA | 6 | 128 | 21.3 | 0 | 51 | 0 | ||
| 5. Michael Pittman Jr., WR | IND | L 27-24 vs. LAR | 8 | 123 | 15.4 | 0 | 42 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Bobby Wagner |
1. Bobby Wagner, LB | SEA | L 33-30 vs. TEN | 16 | 4 | 20 | 1.0 | 0 | 0 | 0 |
| 2. De'Vondre Campbell, LB | GB | W 35-17 vs. DET | 10 | 3 | 13 | 0.0 | 0 | 1 | 0 | |
| 3. Demario Davis, LB | NO | L 26-7 at CAR | 8 | 4 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Anthony Hitchens, LB | KC | L 36-35 at BAL | 8 | 4 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Robert Spillane, LB | PIT | L 26-17 vs. LV | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |