| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | W 42-36 vs. BUF | 33 | 44 | 378 | 3 | 0 | 2 | 0 | 123.1 |
| 2. Matthew Stafford, QB | LAR | W 30-27 at TB | 28 | 38 | 366 | 2 | 0 | 2 | 0 | 121.2 | |
| 3. Joe Burrow, QB | CIN | W 19-16 at TEN | 28 | 37 | 348 | 0 | 1 | 9 | 0 | 93.1 | |
| 4. Josh Allen, QB | BUF | L 42-36 at KC | 27 | 37 | 329 | 4 | 0 | 2 | 0 | 136.0 | |
| 5. Tom Brady, QB | TB | L 30-27 vs. LAR | 30 | 54 | 329 | 1 | 1 | 3 | 1 | 72.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
|
Patrick Mahomes |
1. Patrick Mahomes, QB | KC | W 42-36 vs. BUF | 7 | 69 | 9.9 | 1 | 34 | 0 | |
| 2. Josh Allen, QB | BUF | L 42-36 at KC | 11 | 68 | 6.2 | 0 | 14 | 0 | ||
| 3. D'Onta Foreman, RB | TEN | L 19-16 vs. CIN | 4 | 66 | 16.5 | 0 | 45 | 0 | ||
| 4. Derrick Henry, RB | TEN | L 19-16 vs. CIN | 20 | 62 | 3.1 | 1 | 9 | 0 | ||
| 5. Clyde Edwards-Helaire, RB | KC | W 42-36 vs. BUF | 7 | 60 | 8.6 | 0 | 22 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Gabe Davis |
1. Gabe Davis, WR | BUF | L 42-36 at KC | 8 | 201 | 25.1 | 4 | 75 | 0 | |
| 2. Cooper Kupp, WR | LAR | W 30-27 at TB | 9 | 183 | 20.3 | 1 | 70 | 1 | ||
| 3. Tyreek Hill, WR | KC | W 42-36 vs. BUF | 11 | 150 | 13.6 | 1 | 64 | 0 | ||
| 4. A.J. Brown, WR | TEN | L 19-16 vs. CIN | 5 | 142 | 28.4 | 1 | 41 | 0 | ||
| 5. Aaron Jones Sr., RB | GB | L 13-10 vs. SF | 9 | 129 | 14.3 | 0 | 75 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Lavonte David |
1. Lavonte David, LB | TB | L 30-27 vs. LAR | 7 | 4 | 11 | 0.0 | 0 | 0 | 0 |
| 2. Matt Milano, LB | BUF | L 42-36 at KC | 6 | 5 | 11 | 0.0 | 0 | 0 | 0 | |
| 3. Zach Cunningham, LB | TEN | L 19-16 vs. CIN | 8 | 2 | 10 | 0.0 | 0 | 0 | 0 | |
| 4. Antoine Winfield Jr., S | TB | L 30-27 vs. LAR | 8 | 1 | 9 | 0.0 | 1 | 0 | 0 | |
| 5. Tremaine Edmunds, LB | BUF | L 42-36 at KC | 7 | 2 | 9 | 0.0 | 0 | 0 | 0 | |