| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Kyler Murray |
1. Kyler Murray, QB | ARI | L 30-23 vs. LAR | 32 | 49 | 383 | 0 | 2 | 4 | 0 | 72.1 |
| 2. Tom Brady, QB | TB | W 33-27 vs. BUF | 31 | 46 | 363 | 2 | 0 | 2 | 0 | 105.6 | |
| 3. Joe Burrow, QB | CIN | L 26-23 vs. SF | 25 | 34 | 348 | 2 | 0 | 5 | 0 | 125.6 | |
| 4. Aaron Rodgers, QB | GB | W 45-30 vs. CHI | 29 | 37 | 341 | 4 | 0 | 3 | 0 | 141.1 | |
| 5. Davis Mills, QB | HOU | L 33-13 vs. SEA | 33 | 49 | 331 | 1 | 0 | 2 | 0 | 93.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Dalvin Cook |
1. Dalvin Cook, RB | MIN | W 36-28 vs. PIT | 27 | 205 | 7.6 | 2 | 30 | 0 | |
| 2. Rashaad Penny, RB | SEA | W 33-13 at HOU | 16 | 137 | 8.6 | 2 | 47 | 0 | ||
| 3. Alvin Kamara, RB | NO | W 30-9 at NYJ | 27 | 120 | 4.4 | 1 | 16 | 0 | ||
| 4. Leonard Fournette, RB | TB | W 33-27 vs. BUF | 19 | 113 | 5.9 | 1 | 47 | 0 | ||
| 5. Melvin Gordon III, RB | DEN | W 38-10 vs. DET | 24 | 111 | 4.6 | 2 | 16 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
George Kittle |
1. George Kittle, TE | SF | W 26-23 at CIN | 13 | 151 | 11.6 | 1 | 21 | 0 | |
| 2. Tyler Lockett, WR | SEA | W 33-13 at HOU | 5 | 142 | 28.4 | 1 | 55 | 0 | ||
| 3. Cooper Kupp, WR | LAR | W 30-23 at ARI | 13 | 123 | 9.5 | 1 | 44 | 0 | ||
| 4. Davante Adams, WR | GB | W 45-30 vs. CHI | 10 | 121 | 12.1 | 2 | 38 | 0 | ||
| 5. Hunter Renfrow, WR | LV | L 48-9 at KC | 13 | 117 | 9.0 | 1 | 19 | 1 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
C.J. Mosley |
1. C.J. Mosley, LB | NYJ | L 30-9 vs. NO | 11 | 6 | 17 | 0.0 | 0 | 0 | 0 |
| 2. De'Vondre Campbell, LB | GB | W 45-30 vs. CHI | 9 | 7 | 16 | 0.0 | 0 | 0 | 0 | |
| 3. Bobby Wagner, LB | SEA | W 33-13 at HOU | 6 | 9 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Josh Woods, LB | DET | L 38-10 at DEN | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Jeremy Chinn, S | CAR | L 29-21 vs. ATL | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |