| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Mike White |
1. Mike White, QB | NYJ | W 34-31 vs. CIN | 37 | 45 | 405 | 3 | 2 | 2 | 0 | 107.9 |
| 2. Tom Brady, QB | TB | L 36-27 at NO | 28 | 40 | 375 | 4 | 2 | 3 | 1 | 112.0 | |
| 3. Cooper Rush, QB | DAL | W 20-16 at MIN | 24 | 40 | 325 | 2 | 1 | 3 | 1 | 92.2 | |
| 4. Jimmy Garoppolo, QB | SF | W 33-22 at CHI | 17 | 28 | 322 | 0 | 0 | 0 | 0 | 100.6 | |
| 5. Davis Mills, QB | HOU | L 38-22 vs. LAR | 29 | 38 | 310 | 2 | 1 | 5 | 0 | 106.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Elijah Mitchell |
1. Elijah Mitchell, RB | SF | W 33-22 at CHI | 18 | 137 | 7.6 | 1 | 39 | 0 | |
| 2. Justin Fields, QB | CHI | L 33-22 vs. SF | 10 | 103 | 10.3 | 1 | 22 | 0 | ||
| 3. Najee Harris, RB | PIT | W 15-10 at CLE | 26 | 91 | 3.5 | 1 | 11 | 0 | ||
| 4. Darrell Henderson Jr., RB | LAR | W 38-22 at HOU | 14 | 90 | 6.4 | 1 | 19 | 0 | ||
| 5. Chuba Hubbard, RB | CAR | W 19-13 at ATL | 24 | 82 | 3.4 | 1 | 9 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Deebo Samuel Sr. |
1. Deebo Samuel Sr., WR | SF | W 33-22 at CHI | 6 | 171 | 28.5 | 0 | 83 | 0 | |
| 2. A.J. Brown, WR | TEN | W 34-31 at IND | 10 | 155 | 15.5 | 1 | 57 | 0 | ||
| 3. Tyler Lockett, WR | SEA | W 31-7 vs. JAX | 12 | 142 | 11.8 | 0 | 28 | 0 | ||
| 4. Chris Godwin Jr., WR | TB | L 36-27 at NO | 8 | 140 | 17.5 | 1 | 44 | 0 | ||
| 5. Amari Cooper, WR | DAL | W 20-16 at MIN | 8 | 122 | 15.3 | 1 | 33 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Foyesade Oluokun |
1. Foyesade Oluokun, LB | ATL | L 19-13 vs. CAR | 10 | 6 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Deion Jones, LB | ATL | L 19-13 vs. CAR | 10 | 4 | 14 | 0.0 | 1 | 0 | 0 | |
| 3. Bobby Wagner, LB | SEA | W 31-7 vs. JAX | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. T.J. Edwards, LB | PHI | W 44-6 at DET | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Derwin James Jr., S | LAC | L 27-24 vs. NE | 7 | 6 | 13 | 0.0 | 1 | 0 | 0 | |