| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Joe Burrow |
1. Joe Burrow, QB | CIN | W 41-21 vs. BAL | 37 | 46 | 525 | 4 | 0 | 3 | 0 | 143.2 |
| 2. Justin Herbert, QB | LAC | L 41-29 at HOU | 27 | 35 | 336 | 1 | 2 | 1 | 0 | 92.1 | |
| 3. Dak Prescott, QB | DAL | W 56-14 vs. WSH | 28 | 39 | 330 | 4 | 0 | 3 | 0 | 131.4 | |
| 4. Jimmy Garoppolo, QB | SF | L 20-17 at TEN | 26 | 35 | 322 | 1 | 2 | 2 | 0 | 88.1 | |
| 5. Kirk Cousins, QB | MIN | L 30-23 vs. LAR | 27 | 38 | 315 | 1 | 1 | 3 | 0 | 93.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Rex Burkhead |
1. Rex Burkhead, RB | HOU | W 41-29 vs. LAC | 22 | 149 | 6.8 | 2 | 36 | 0 | |
| 2. Rashaad Penny, RB | SEA | L 25-24 vs. CHI | 17 | 135 | 7.9 | 1 | 32 | 0 | ||
| 3. Sony Michel, RB | LAR | W 30-23 at MIN | 27 | 131 | 4.9 | 1 | 16 | 0 | ||
| 4. Josh Jacobs, RB | LV | W 17-13 vs. DEN | 27 | 129 | 4.8 | 0 | 19 | 1 | ||
| 5. Nick Chubb, RB | CLE | L 24-22 at GB | 17 | 126 | 7.4 | 1 | 27 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tee Higgins |
1. Tee Higgins, WR | CIN | W 41-21 vs. BAL | 12 | 194 | 16.2 | 2 | 52 | 0 | |
| 2. Deebo Samuel Sr., WR | SF | L 20-17 at TEN | 9 | 159 | 17.7 | 0 | 56 | 0 | ||
| 3. A.J. Brown, WR | TEN | W 20-17 vs. SF | 11 | 145 | 13.2 | 1 | 42 | 0 | ||
| 4. Isaiah McKenzie, WR | BUF | W 33-21 at NE | 11 | 125 | 11.4 | 1 | 28 | 0 | ||
| 5. Mark Andrews, TE | BAL | L 41-21 at CIN | 8 | 125 | 15.6 | 1 | 28 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
T.J. Edwards |
1. T.J. Edwards, LB | PHI | W 34-10 vs. NYG | 6 | 10 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Foyesade Oluokun, LB | ATL | W 20-16 vs. DET | 8 | 6 | 14 | 0.0 | 0 | 1 | 0 | |
| 3. De'Vondre Campbell, LB | GB | W 24-22 vs. CLE | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Budda Baker, S | ARI | L 22-16 vs. IND | 7 | 6 | 13 | 1.0 | 0 | 0 | 0 | |
| 5. Jonas Griffith, LB | DEN | L 17-13 at LV | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |