| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Tom Brady |
1. Tom Brady, QB | TB | W 30-17 at ATL | 38 | 51 | 368 | 4 | 1 | 0 | 0 | 112.2 |
| 2. Kirk Cousins, QB | MIN | L 29-27 at DET | 30 | 40 | 340 | 2 | 0 | 3 | 1 | 116.7 | |
| 3. Justin Herbert, QB | LAC | W 41-22 at CIN | 26 | 35 | 317 | 3 | 1 | 4 | 0 | 118.4 | |
| 4. Joe Burrow, QB | CIN | L 41-22 vs. LAC | 24 | 40 | 300 | 1 | 2 | 6 | 1 | 70.8 | |
| 5. Jimmy Garoppolo, QB | SF | L 30-23 at SEA | 20 | 30 | 299 | 2 | 2 | 1 | 0 | 93.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jonathan Taylor |
1. Jonathan Taylor, RB | IND | W 31-0 at HOU | 32 | 143 | 4.5 | 2 | 16 | 1 | |
| 2. Sony Michel, RB | LAR | W 37-7 vs. JAX | 24 | 121 | 5.0 | 1 | 25 | 0 | ||
| 3. Miles Sanders, RB | PHI | W 33-18 at NYJ | 24 | 120 | 5.0 | 0 | 34 | 0 | ||
| 4. Damien Harris, RB | NE | W 14-10 at BUF | 10 | 111 | 11.1 | 1 | 64 | 0 | ||
| 5. Javonte Williams, RB | DEN | L 22-9 at KC | 23 | 102 | 4.4 | 0 | 14 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Justin Jefferson |
1. Justin Jefferson, WR | MIN | L 29-27 at DET | 11 | 182 | 16.5 | 1 | 48 | 0 | |
| 2. George Kittle, TE | SF | L 30-23 at SEA | 9 | 181 | 20.1 | 2 | 48 | 0 | ||
| 3. Chris Godwin Jr., WR | TB | W 30-17 at ATL | 15 | 143 | 9.5 | 0 | 36 | 0 | ||
| 4. Tee Higgins, WR | CIN | L 41-22 vs. LAC | 9 | 138 | 15.3 | 1 | 29 | 0 | ||
| 5. Russell Gage Jr., WR | ATL | L 30-17 vs. TB | 11 | 130 | 11.8 | 0 | 19 | 1 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Kamu Grugier-Hill |
1. Kamu Grugier-Hill, LB | HOU | L 31-0 vs. IND | 10 | 10 | 20 | 1.0 | 0 | 0 | 0 |
| 2. Azeez Al-Shaair, LB | SF | L 30-23 at SEA | 11 | 4 | 15 | 0.5 | 1 | 0 | 0 | |
| 3. Nick Vigil, LB | MIN | L 29-27 at DET | 9 | 6 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Foyesade Oluokun, LB | ATL | L 30-17 vs. TB | 8 | 7 | 15 | 0.0 | 0 | 0 | 0 | |
| 5. C.J. Mosley, LB | NYJ | L 33-18 vs. PHI | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |