| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Justin Herbert |
1. Justin Herbert, QB | LAC | L 35-32 at LV | 34 | 64 | 383 | 3 | 1 | 3 | 0 | 80.4 |
| 2. Tom Brady, QB | TB | W 41-17 vs. CAR | 29 | 37 | 326 | 3 | 0 | 1 | 0 | 130.4 | |
| 3. Andy Dalton, QB | CHI | L 31-17 at MIN | 33 | 48 | 325 | 1 | 2 | 7 | 0 | 77.2 | |
| 4. Jimmy Garoppolo, QB | SF | W 27-24 at LAR | 23 | 32 | 316 | 1 | 2 | 3 | 0 | 87.5 | |
| 5. Davis Mills, QB | HOU | L 28-25 vs. TEN | 23 | 33 | 301 | 3 | 0 | 2 | 0 | 128.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Rashaad Penny |
1. Rashaad Penny, RB | SEA | W 38-30 at ARI | 23 | 190 | 8.3 | 1 | 62 | 0 | |
| 2. Latavius Murray, WR | BAL | L 16-13 vs. PIT | 16 | 150 | 9.4 | 1 | 46 | 0 | ||
| 3. Antonio Gibson, RB | WSH | W 22-7 at NYG | 21 | 146 | 7.0 | 1 | 27 | 0 | ||
| 4. Alvin Kamara, RB | NO | W 30-20 at ATL | 30 | 146 | 4.9 | 0 | 27 | 0 | ||
| 5. Josh Jacobs, RB | LV | W 35-32 vs. LAC | 26 | 132 | 5.1 | 1 | 28 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Rob Gronkowski |
1. Rob Gronkowski, TE | TB | W 41-17 vs. CAR | 7 | 137 | 19.6 | 0 | 42 | 0 | |
| 2. Darnell Mooney, WR | CHI | L 31-17 at MIN | 12 | 126 | 10.5 | 0 | 19 | 0 | ||
| 3. Russell Gage Jr., WR | ATL | L 30-20 vs. NO | 9 | 126 | 14.0 | 1 | 26 | 0 | ||
| 4. Mike Williams, WR | LAC | L 35-32 at LV | 9 | 119 | 13.2 | 1 | 47 | 0 | ||
| 5. Cedrick Wilson Jr., WR | DAL | W 51-26 at PHI | 5 | 119 | 23.8 | 2 | 37 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Jordyn Brooks |
1. Jordyn Brooks, LB | SEA | W 38-30 at ARI | 15 | 5 | 20 | 0.0 | 0 | 0 | 0 |
| 2. Ja'Whaun Bentley, LB | NE | L 33-24 at MIA | 9 | 8 | 17 | 0.0 | 0 | 0 | 0 | |
| 3. Tracy Walker III, S | DET | W 37-30 vs. GB | 10 | 4 | 14 | 0.0 | 0 | 1 | 0 | |
| 4. C.J. Mosley, LB | NYJ | L 27-10 at BUF | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Foyesade Oluokun, LB | ATL | L 30-20 vs. NO | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |