| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Lamar Jackson |
1. Lamar Jackson, QB | BAL | W 31-25 vs. IND | 37 | 43 | 442 | 4 | 0 | 2 | 1 | 140.5 |
| 2. Tom Brady, QB | TB | W 45-17 vs. MIA | 30 | 41 | 411 | 5 | 0 | 2 | 0 | 144.4 | |
| 3. Carson Wentz, QB | IND | L 31-25 at BAL | 25 | 35 | 402 | 2 | 0 | 2 | 1 | 128.5 | |
| 4. Justin Herbert, QB | LAC | W 47-42 vs. CLE | 26 | 43 | 398 | 4 | 0 | 2 | 0 | 122.0 | |
| 5. Matthew Stafford, QB | LAR | W 26-17 at SEA | 25 | 37 | 365 | 1 | 1 | 1 | 0 | 97.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Nick Chubb |
1. Nick Chubb, RB | CLE | L 47-42 at LAC | 21 | 161 | 7.7 | 1 | 52 | 0 | |
| 2. James Robinson, RB | JAX | L 37-19 vs. TEN | 18 | 149 | 8.3 | 1 | 58 | 0 | ||
| 3. Derrick Henry, RB | TEN | W 37-19 at JAX | 29 | 130 | 4.5 | 3 | 15 | 0 | ||
| 4. Najee Harris, RB | PIT | W 27-19 vs. DEN | 23 | 122 | 5.3 | 1 | 20 | 0 | ||
| 5. Alexander Mattison, RB | MIN | W 19-17 vs. DET | 25 | 113 | 4.5 | 0 | 48 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Davante Adams |
1. Davante Adams, WR | GB | W 25-22 at CIN | 11 | 206 | 18.7 | 1 | 59 | 0 | |
| 2. Kadarius Toney, WR | NYG | L 44-20 at DAL | 10 | 189 | 18.9 | 0 | 38 | 0 | ||
| 3. Mike Williams, WR | LAC | W 47-42 vs. CLE | 8 | 165 | 20.6 | 2 | 72 | 0 | ||
| 4. Ja'Marr Chase, WR | CIN | L 25-22 vs. GB | 6 | 159 | 26.5 | 1 | 70 | 0 | ||
| 5. Robert Woods, WR | LAR | W 26-17 at SEA | 12 | 150 | 12.5 | 0 | 25 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Derwin James Jr. |
1. Derwin James Jr., S | LAC | W 47-42 vs. CLE | 9 | 7 | 16 | 1.0 | 1 | 0 | 0 |
| 2. Alex Singleton, LB | PHI | W 21-18 at CAR | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Denzel Perryman, LB | LV | L 20-9 vs. CHI | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Pete Werner, LB | NO | W 33-22 at WSH | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Shaquille Leonard, LB | IND | L 31-25 at BAL | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |