| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Joe Burrow |
1. Joe Burrow, QB | CIN | W 34-31 vs. KC | 30 | 39 | 446 | 4 | 0 | 4 | 0 | 148.0 |
| 2. Tom Brady, QB | TB | W 28-24 at NYJ | 34 | 50 | 410 | 3 | 1 | 1 | 0 | 104.6 | |
| 3. Matthew Stafford, QB | LAR | W 20-19 at BAL | 26 | 35 | 309 | 2 | 2 | 1 | 1 | 96.0 | |
| 4. Aaron Rodgers, QB | GB | W 37-10 vs. MIN | 29 | 38 | 288 | 2 | 0 | 0 | 0 | 114.8 | |
| 5. Kyler Murray, QB | ARI | W 25-22 at DAL | 26 | 38 | 263 | 2 | 0 | 1 | 0 | 105.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Najee Harris |
1. Najee Harris, RB | PIT | W 26-14 vs. CLE | 28 | 188 | 6.7 | 1 | 37 | 0 | |
| 2. Rashaad Penny, RB | SEA | W 51-29 vs. DET | 25 | 170 | 6.8 | 2 | 37 | 0 | ||
| 3. D'Onta Foreman, RB | TEN | W 34-3 vs. MIA | 26 | 132 | 5.1 | 1 | 35 | 0 | ||
| 4. Elijah Mitchell, RB | SF | W 23-7 vs. HOU | 21 | 119 | 5.7 | 0 | 37 | 0 | ||
| 5. Devin Singletary, RB | BUF | W 29-15 vs. ATL | 23 | 110 | 4.8 | 2 | 20 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Ja'Marr Chase |
1. Ja'Marr Chase, WR | CIN | W 34-31 vs. KC | 11 | 266 | 24.2 | 3 | 72 | 0 | |
| 2. Davante Adams, WR | GB | W 37-10 vs. MIN | 11 | 136 | 12.4 | 1 | 30 | 0 | ||
| 3. Zay Jones, WR | LV | W 23-20 at IND | 8 | 120 | 15.0 | 0 | 42 | 0 | ||
| 4. Rob Gronkowski, TE | TB | W 28-24 at NYJ | 7 | 115 | 16.4 | 0 | 24 | 0 | ||
| 5. Amon-Ra St. Brown, WR | DET | L 51-29 at SEA | 8 | 111 | 13.9 | 1 | 31 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Fred Warner |
1. Fred Warner, LB | SF | W 23-7 vs. HOU | 7 | 8 | 15 | 0.0 | 1 | 0 | 0 |
| 2. T.J. Edwards, LB | PHI | W 20-16 at WSH | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. C.J. Mosley, LB | NYJ | L 28-24 vs. TB | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Foyesade Oluokun, LB | ATL | L 29-15 at BUF | 7 | 6 | 13 | 0.0 | 0 | 1 | 0 | |
| 5. Tracy Walker III, S | DET | L 51-29 at SEA | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |